Novel benzo[ b ]thiophene derivatives as new potential antidepressants with rapid onset of action

Luis Berrade; Bárbara Aisa; María J. Ramirez; Silvia Galiano; Salvatore Guccione; Lise Román Moltzau; Finn Olav Levy; Ferdinando Nicoletti; Giuseppe Battaglia; Gemma Molinaro; Ignacio Aldana; Antonio Monge; Silvia Perez-Silanes

doi:10.1021/jm2000773

Novel benzo[ b ]thiophene derivatives as new potential antidepressants with rapid onset of action

Luis Berrade, Bárbara Aisa, María J. Ramirez, Silvia Galiano, Salvatore Guccione, Lise Román Moltzau, Finn Olav Levy, Ferdinando Nicoletti, Giuseppe Battaglia, Gemma Molinaro, Ignacio Aldana, Antonio Monge, Silvia Perez-Silanes

Research output: Contribution to journal › Article › peer-review

91 Scopus citations

Abstract

We report benzo[b]thiophene derivatives synthesized according to a dual strategy. 8j, 9c, and 9e with affinity values toward 5-HT₇R and 5-HTT were selected to probe their antidepressant activity in vivo using the forced swimming text (FST). The results showed significant antidepressant activity after chronic treatment. 9c was effective in reducing the immobility time in FST even after acute treatment. These findings identify these compounds as a new class of antidepressants with a rapid onset of action.

Original language	English (US)
Pages (from-to)	3086-3090
Number of pages	5
Journal	Journal of Medicinal Chemistry
Volume	54
Issue number	8
DOIs	https://doi.org/10.1021/jm2000773
State	Published - Apr 28 2011

ASJC Scopus subject areas

Molecular Medicine
Drug Discovery

Access to Document

10.1021/jm2000773

Cite this

Berrade, L., Aisa, B., Ramirez, M. J., Galiano, S., Guccione, S., Moltzau, L. R., Levy, F. O., Nicoletti, F., Battaglia, G., Molinaro, G., Aldana, I., Monge, A., & Perez-Silanes, S. (2011). Novel benzo[ b ]thiophene derivatives as new potential antidepressants with rapid onset of action. Journal of Medicinal Chemistry, 54(8), 3086-3090. https://doi.org/10.1021/jm2000773

@article{b95ed2dd1c1c45118233aeb816f3d435,

title = "Novel benzo[ b ]thiophene derivatives as new potential antidepressants with rapid onset of action",

abstract = "We report benzo[b]thiophene derivatives synthesized according to a dual strategy. 8j, 9c, and 9e with affinity values toward 5-HT7R and 5-HTT were selected to probe their antidepressant activity in vivo using the forced swimming text (FST). The results showed significant antidepressant activity after chronic treatment. 9c was effective in reducing the immobility time in FST even after acute treatment. These findings identify these compounds as a new class of antidepressants with a rapid onset of action.",

author = "Luis Berrade and B{\'a}rbara Aisa and Ramirez, {Mar{\'i}a J.} and Silvia Galiano and Salvatore Guccione and Moltzau, {Lise Rom{\'a}n} and Levy, {Finn Olav} and Ferdinando Nicoletti and Giuseppe Battaglia and Gemma Molinaro and Ignacio Aldana and Antonio Monge and Silvia Perez-Silanes",

year = "2011",

month = apr,

day = "28",

doi = "10.1021/jm2000773",

language = "English (US)",

volume = "54",

pages = "3086--3090",

journal = "Journal of Medicinal Chemistry",

issn = "0022-2623",

publisher = "American Chemical Society",

number = "8",

}

TY - JOUR

T1 - Novel benzo[ b ]thiophene derivatives as new potential antidepressants with rapid onset of action

AU - Berrade, Luis

AU - Aisa, Bárbara

AU - Ramirez, María J.

AU - Galiano, Silvia

AU - Guccione, Salvatore

AU - Moltzau, Lise Román

AU - Levy, Finn Olav

AU - Nicoletti, Ferdinando

AU - Battaglia, Giuseppe

AU - Molinaro, Gemma

AU - Aldana, Ignacio

AU - Monge, Antonio

AU - Perez-Silanes, Silvia

PY - 2011/4/28

Y1 - 2011/4/28

N2 - We report benzo[b]thiophene derivatives synthesized according to a dual strategy. 8j, 9c, and 9e with affinity values toward 5-HT7R and 5-HTT were selected to probe their antidepressant activity in vivo using the forced swimming text (FST). The results showed significant antidepressant activity after chronic treatment. 9c was effective in reducing the immobility time in FST even after acute treatment. These findings identify these compounds as a new class of antidepressants with a rapid onset of action.

AB - We report benzo[b]thiophene derivatives synthesized according to a dual strategy. 8j, 9c, and 9e with affinity values toward 5-HT7R and 5-HTT were selected to probe their antidepressant activity in vivo using the forced swimming text (FST). The results showed significant antidepressant activity after chronic treatment. 9c was effective in reducing the immobility time in FST even after acute treatment. These findings identify these compounds as a new class of antidepressants with a rapid onset of action.

UR - http://www.scopus.com/inward/record.url?scp=79955408540&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79955408540&partnerID=8YFLogxK

U2 - 10.1021/jm2000773

DO - 10.1021/jm2000773

M3 - Article

C2 - 21469694

AN - SCOPUS:79955408540

SN - 0022-2623

VL - 54

SP - 3086

EP - 3090

JO - Journal of Medicinal Chemistry

JF - Journal of Medicinal Chemistry

IS - 8

ER -

Novel benzo[ b ]thiophene derivatives as new potential antidepressants with rapid onset of action

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this