Not without cause: Vibrio parahaemolyticus induces acute autophagy and cell death

Dara L. Burdette, Melanie L. Yarbrough, Kim Orth

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


Vibrio parahaemolyticus (V. parahaemolyticus) is a gram-negative halophillic bacterium that causes worldwide seafood-borne gastroenteritis. The prevalence of V. parahaemolyticus in the environment and incidence of infection have been linked to rising water temperatures caused by global warming. Among its virulence factors, V. parahaemolyticus harbors two type III secretion systems (T3SS). Recently, we have shown that T3SS1 induces rapid cellular death that initiates with acute autophagy, as measured by LC3 lipidation and accumulation of early autophagosomal vesicles. While not the first characterized pathogen to usurp autophagy, this is the first example of an extracellular pathogen that exploits this pathway for its own benefit. Here we discuss possible roles for the induction of autophagy during infection and discuss how V. parahaemolyticus-induced autophagy provides insight into key regulatory steps that govern the decision between apoptosis and autophagy.

Original languageEnglish (US)
Pages (from-to)100-102
Number of pages3
Issue number1
StatePublished - Jan 1 2009


  • Apoptosis
  • Autophagy
  • Cell death
  • Infection
  • Proinflammatory
  • Type III secretion
  • Vibrio parahaemolyticus

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology


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