TY - JOUR
T1 - Not just pretty eyes
T2 - Drosophila eye-colour mutations and lysosomal delivery
AU - Lloyd, Vett
AU - Ramaswami, Mani
AU - Krämer, Helmut
N1 - Funding Information:
We thank B. Wakimoto and E. Sevrioukov for permission to quote unpublished results, and J. Robinson, R. Narayanan, S. Emr and B. Wakimoto for helpful comments on the manuscript. Work in the authors' labs is supported by the Mt Allison senate committee on research and the Crake Foundation (V. L.), the NINDS, NSF, Sloan and McKnight Foundations (M. R.) and the NEI and the Welch Foundation (H. K.).
PY - 1998/12/1
Y1 - 1998/12/1
N2 - Analysis of Drosophila eye-colour mutations has mane seminal contributions to the fields of genetics and biochemistry. Recent findings suggest that a subset of eye-colour genes is crucial for vesicullar transport of proteins to pigment granules, specialized lysosomes of eye-pigment cells. Thus, classical work describing more than 85 eye-colour mutations and their genetic interactions offers a remarkable, untapped resource for the genetic analysis of protein delivery to lysosomes.
AB - Analysis of Drosophila eye-colour mutations has mane seminal contributions to the fields of genetics and biochemistry. Recent findings suggest that a subset of eye-colour genes is crucial for vesicullar transport of proteins to pigment granules, specialized lysosomes of eye-pigment cells. Thus, classical work describing more than 85 eye-colour mutations and their genetic interactions offers a remarkable, untapped resource for the genetic analysis of protein delivery to lysosomes.
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U2 - 10.1016/S0962-8924(98)01270-7
DO - 10.1016/S0962-8924(98)01270-7
M3 - Article
C2 - 9714595
AN - SCOPUS:0032404540
SN - 0962-8924
VL - 8
SP - 257
EP - 259
JO - Trends in Cell Biology
JF - Trends in Cell Biology
IS - 7
ER -