Norbin is an endogenous regulator of metabotropic glutamate receptor 5 signaling

Hong Wang, Linda Westin, Yi Nong, Shari Birnbaum, Jacob Bendor, Hjalmar Brismar, Eric Nestler, Anita Aperia, Marc Flajolet, Paul Greengard

Research output: Contribution to journalArticlepeer-review

88 Scopus citations


Metabotropic glutamate receptor 5 (mGluR5) is highly expressed in the mammalian central nervous system (CNS). It is involved in multiple physiological functions and is a target for treatment of various CNS disorders, including schizophrenia. We report that Norbin, a neuron-specific protein, physically interacts with mGluR5 in vivo, increases the cell surface localization of the receptor, and positively regulates mGluR5 signaling. Genetic deletion of Norbin attenuates mGluR5-dependent stable changes in synaptic function measured as long-term depression or long-term potentiation of synaptic transmission in the hippocampus. As with mGluR5 knockout mice or mice treated with mGluR5-selective antagonists, Norbin knockout mice showed a behavioral phenotype associated with a rodent model of schizophrenia, as indexed by alterations both in sensorimotor gating and psychotomimetic-induced locomotor activity.

Original languageEnglish (US)
Pages (from-to)1554-1557
Number of pages4
Issue number5959
StatePublished - Dec 11 2009

ASJC Scopus subject areas

  • General


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