Nonphotic phase-shifting in Clock mutant mice

Etienne Challet, Joseph S. Takahashi, Fred W. Turek

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


Nonphotic phase-shifting was studied in mice bearing the Clock mutation. First, free-running mice heterozygous for Clock and wild-type mice were induced to become active through a 4-h confinement to a novel running over 3 days. Second, mice exposed to light-dark cycle received daily hypocaloric food during 2 weeks, before being transferred to constant darkness and fed ad libitum. Behavioral activation during the mid-subjective day induced 40-min phase advances in the locomotor activity rhythm of wild-type mice, whereas it produced 50-min phase delays in the circadian behavior of Clock/+ mice. Calorie restriction phase-advanced by 80 min the locomotor activity rhythm in wild-type mice, but not in Clock/+ mice. Therefore, the response of the Clock/+ mice to nonphotic phase shifting differs from that of wild-type mice. Copyright (C) 2000 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)398-403
Number of pages6
JournalBrain Research
Issue number2
StatePublished - Mar 24 2000


  • Circadian rhythm
  • Clock gene
  • Light-entrainable pacemaker
  • Locomotor behavior
  • Photic synchronization
  • Suprachiasmatic nucleus

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology


Dive into the research topics of 'Nonphotic phase-shifting in Clock mutant mice'. Together they form a unique fingerprint.

Cite this