Noninvasive perfusion MRI in Alzheimer's disease: A preliminary report

T. A. Sandson, M. O'Connor, R. A. Sperling, R. R. Edelman, S. Warach

Research output: Contribution to journalArticlepeer-review

62 Scopus citations


We performed functional MRI using the echo-planar imaging and signal targeting with alternating radio frequency (EPISTAR) technique in 11 patients with Alzheimer's disease (AD) and 8 age-matched control subjects. Seven of the AD patients had qualitatively apparent focal areas of hypoperfusion in the posterior temporoparietal-occipital regions. At the earliest inversion time producing cortical enhancement, the ratios of parietooccipital and temporo-occipital to whole slice signal intensity were significantly lower in the AD patients than in the controls. Parieto-occipital hypoperfusion correlated with dementia severity as measured by the Blessed Dementia Scale. EPISTAR may prove to be a rapid, noninvasive alternative to other functional neuroimaging modalities in the evaluation of patients with dementia.

Original languageEnglish (US)
Pages (from-to)1339-1342
Number of pages4
Issue number5
StatePublished - Nov 1996

ASJC Scopus subject areas

  • Clinical Neurology


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