Noninvasive perfusion MRI in Alzheimer's disease: A preliminary report

T. A. Sandson; M. O'Connor; R. A. Sperling; R. R. Edelman; S. Warach

doi:10.1212/WNL.47.5.1339

Noninvasive perfusion MRI in Alzheimer's disease: A preliminary report

T. A. Sandson, M. O'Connor, R. A. Sperling, R. R. Edelman, S. Warach

Neurology & Neurotherapeutics

Research output: Contribution to journal › Article › peer-review

62 Scopus citations

Abstract

We performed functional MRI using the echo-planar imaging and signal targeting with alternating radio frequency (EPISTAR) technique in 11 patients with Alzheimer's disease (AD) and 8 age-matched control subjects. Seven of the AD patients had qualitatively apparent focal areas of hypoperfusion in the posterior temporoparietal-occipital regions. At the earliest inversion time producing cortical enhancement, the ratios of parietooccipital and temporo-occipital to whole slice signal intensity were significantly lower in the AD patients than in the controls. Parieto-occipital hypoperfusion correlated with dementia severity as measured by the Blessed Dementia Scale. EPISTAR may prove to be a rapid, noninvasive alternative to other functional neuroimaging modalities in the evaluation of patients with dementia.

Original language	English (US)
Pages (from-to)	1339-1342
Number of pages	4
Journal	Neurology
Volume	47
Issue number	5
DOIs	https://doi.org/10.1212/WNL.47.5.1339
State	Published - Nov 1996

ASJC Scopus subject areas

Clinical Neurology

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title = "Noninvasive perfusion MRI in Alzheimer's disease: A preliminary report",

abstract = "We performed functional MRI using the echo-planar imaging and signal targeting with alternating radio frequency (EPISTAR) technique in 11 patients with Alzheimer's disease (AD) and 8 age-matched control subjects. Seven of the AD patients had qualitatively apparent focal areas of hypoperfusion in the posterior temporoparietal-occipital regions. At the earliest inversion time producing cortical enhancement, the ratios of parietooccipital and temporo-occipital to whole slice signal intensity were significantly lower in the AD patients than in the controls. Parieto-occipital hypoperfusion correlated with dementia severity as measured by the Blessed Dementia Scale. EPISTAR may prove to be a rapid, noninvasive alternative to other functional neuroimaging modalities in the evaluation of patients with dementia.",

author = "Sandson, {T. A.} and M. O'Connor and Sperling, {R. A.} and Edelman, {R. R.} and S. Warach",

note = "Funding Information: We sincerely thank the families and their clinicians for participating in this study. G. Matthijs, M. McDermott, E. Thompson, S. Timshel, and P. Turnpenny provided additional samples from individuals affected with an SEDL-like phenotype but who were normal for the SEDL ORF. We thank Gen Nishimura, Shiro Ikegawa, and Yukihiro Hasegawa for diagnosing and/or referring a patient. W.G.C. is funded by the Canadian Institute of Health Research, and D.L.R. is funded by National Institutes of Health grant HD22657. This work was supported by the National Health and Medical Research Council of Australia and by National Institutes of Health grant AR45477. ",

year = "1996",

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doi = "10.1212/WNL.47.5.1339",

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AU - Sperling, R. A.

AU - Edelman, R. R.

AU - Warach, S.

N1 - Funding Information: We sincerely thank the families and their clinicians for participating in this study. G. Matthijs, M. McDermott, E. Thompson, S. Timshel, and P. Turnpenny provided additional samples from individuals affected with an SEDL-like phenotype but who were normal for the SEDL ORF. We thank Gen Nishimura, Shiro Ikegawa, and Yukihiro Hasegawa for diagnosing and/or referring a patient. W.G.C. is funded by the Canadian Institute of Health Research, and D.L.R. is funded by National Institutes of Health grant HD22657. This work was supported by the National Health and Medical Research Council of Australia and by National Institutes of Health grant AR45477.

PY - 1996/11

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N2 - We performed functional MRI using the echo-planar imaging and signal targeting with alternating radio frequency (EPISTAR) technique in 11 patients with Alzheimer's disease (AD) and 8 age-matched control subjects. Seven of the AD patients had qualitatively apparent focal areas of hypoperfusion in the posterior temporoparietal-occipital regions. At the earliest inversion time producing cortical enhancement, the ratios of parietooccipital and temporo-occipital to whole slice signal intensity were significantly lower in the AD patients than in the controls. Parieto-occipital hypoperfusion correlated with dementia severity as measured by the Blessed Dementia Scale. EPISTAR may prove to be a rapid, noninvasive alternative to other functional neuroimaging modalities in the evaluation of patients with dementia.

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Noninvasive perfusion MRI in Alzheimer's disease: A preliminary report

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