Noninvasive perfusion imaging of human brain tumors with EPISTAR

J. Gaa, S. Warach, P. Wen, V. Thangaraj, P. Wielopolski, R. R. Edelman

Research output: Contribution to journalArticlepeer-review

39 Scopus citations


A total of 17 patients with histologically proven diagnoses of low-grade astrocytoma (n = 4), high-grade astrocytoma (n = 8), lymphoma (n = 3), and meningioma (n = 2) were examined by using EPISTAR MR imaging. Meningiomas had the high-est EPISTAR tumor/white matter contrast and low-grade astrocytomas and lymphomas the lowest. High-grade astrocytomas demonstrated elevated EPISTAR signal with marked regional heterogeneity. There was agreement between tumor vascularity by SPECT and EPISTAR in the five cases where both were done. Our results show that tumor vascularity can be assessed qualitatively by using EPISTAR without the need for contrast medium injection.

Original languageEnglish (US)
Pages (from-to)518-522
Number of pages5
JournalEuropean Radiology
Issue number4
StatePublished - 1996


  • Brain
  • Echo-planar imaging
  • Magnetic resonance imaging
  • Neoplasms
  • Perfusion

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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