Nonhomologous End Joining in Eukaryotes

E. Weterings; D. J. Chen

doi:10.1016/B978-0-12-378630-2.00272-3

Nonhomologous End Joining in Eukaryotes

E. Weterings, D. J. Chen

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

This article discusses the core mechanism of the nonhomologous end-joining (NHEJ) process: one of two pathways that mediate the repair of DNA double-strand breaks (DSBs) in eukaryotic cells. Through complex interplay of several enzymes, NHEJ facilitates the capture, tethering, processing, and ligation of the two ends of a broken DNA molecule. The individual roles of all key NHEJ enzymes are discussed, as well as the rare human disease patterns that can arise by impairment of these enzymes. In addition, a brief description is given of cellular processes, other than DSB repair, that also utilize the NHEJ machinery.

Original language	English (US)
Title of host publication	Encyclopedia of Biological Chemistry
Subtitle of host publication	Second Edition
Publisher	Elsevier Inc.
Pages	269-274
Number of pages	6
ISBN (Electronic)	9780123786319
ISBN (Print)	9780123786302
DOIs	https://doi.org/10.1016/B978-0-12-378630-2.00272-3
State	Published - Feb 15 2013

Keywords

Artemis
ATM
Cancer
Cernunnos
DNA double-strand break
DNA repair
DNA-PK
Ionizing radiation
Ku70/80
Ligase IV
NHEJ
Nonhomologous end joining
V(D)J recombination
XLF
XRCC4

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

Access to Document

10.1016/B978-0-12-378630-2.00272-3

Cite this

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abstract = "This article discusses the core mechanism of the nonhomologous end-joining (NHEJ) process: one of two pathways that mediate the repair of DNA double-strand breaks (DSBs) in eukaryotic cells. Through complex interplay of several enzymes, NHEJ facilitates the capture, tethering, processing, and ligation of the two ends of a broken DNA molecule. The individual roles of all key NHEJ enzymes are discussed, as well as the rare human disease patterns that can arise by impairment of these enzymes. In addition, a brief description is given of cellular processes, other than DSB repair, that also utilize the NHEJ machinery.",

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AB - This article discusses the core mechanism of the nonhomologous end-joining (NHEJ) process: one of two pathways that mediate the repair of DNA double-strand breaks (DSBs) in eukaryotic cells. Through complex interplay of several enzymes, NHEJ facilitates the capture, tethering, processing, and ligation of the two ends of a broken DNA molecule. The individual roles of all key NHEJ enzymes are discussed, as well as the rare human disease patterns that can arise by impairment of these enzymes. In addition, a brief description is given of cellular processes, other than DSB repair, that also utilize the NHEJ machinery.

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KW - ATM

KW - Cancer

KW - Cernunnos

KW - DNA double-strand break

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KW - DNA-PK

KW - Ionizing radiation

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KW - Ligase IV

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ER -

Nonhomologous End Joining in Eukaryotes

Abstract

Keywords

ASJC Scopus subject areas

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