Noncoding RNAs: biology and applications—a Keystone Symposia report

Jennifer Cable; Edith Heard; Tetsuro Hirose; Kannanganattu V. Prasanth; Ling Ling Chen; Jonathan E. Henninger; Sofia A. Quinodoz; David L. Spector; Sarah D. Diermeier; Allison M. Porman; Dhiraj Kumar; Mark W. Feinberg; Xiaohua Shen; Juan Pablo Unfried; Rory Johnson; Chun Kan Chen; Jeremy E. Wilusz; Adelheid Lempradl; Sean E. McGeary; Lamia Wahba; Anna Marie Pyle; Amanda E. Hargrove; Matthew D. Simon; Marco Marcia; Róża K. Przanowska; Howard Y. Chang; Samie R. Jaffrey; Lydia M. Contreras; Qi Chen; Junchao Shi; Joshua T. Mendell; Lin He; Erwei Song; John L. Rinn; Mukesh Kumar Lalwani; Murat Can Kalem; Edward B. Chuong; Lynne E. Maquat; Xuhang Liu

doi:10.1111/nyas.14713

Noncoding RNAs: biology and applications—a Keystone Symposia report

Jennifer Cable, Edith Heard, Tetsuro Hirose, Kannanganattu V. Prasanth, Ling Ling Chen, Jonathan E. Henninger, Sofia A. Quinodoz, David L. Spector, Sarah D. Diermeier, Allison M. Porman, Dhiraj Kumar, Mark W. Feinberg, Xiaohua Shen, Juan Pablo Unfried, Rory Johnson, Chun Kan Chen, Jeremy E. Wilusz, Adelheid Lempradl, Sean E. McGeary, Lamia WahbaAnna Marie Pyle, Amanda E. Hargrove, Matthew D. Simon, Marco Marcia, Róża K. Przanowska, Howard Y. Chang, Samie R. Jaffrey, Lydia M. Contreras, Qi Chen, Junchao Shi, Joshua T. Mendell, Lin He, Erwei Song, John L. Rinn, Mukesh Kumar Lalwani, Murat Can Kalem, Edward B. Chuong, Lynne E. Maquat, Xuhang Liu

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

The human transcriptome contains many types of noncoding RNAs, which rival the number of protein-coding species. From long noncoding RNAs (lncRNAs) that are over 200 nucleotides long to piwi-interacting RNAs (piRNAs) of only 20 nucleotides, noncoding RNAs play important roles in regulating transcription, epigenetic modifications, translation, and cell signaling. Roles for noncoding RNAs in disease mechanisms are also being uncovered, and several species have been identified as potential drug targets. On May 11–14, 2021, the Keystone eSymposium “Noncoding RNAs: Biology and Applications” brought together researchers working in RNA biology, structure, and technologies to accelerate both the understanding of RNA basic biology and the translation of those findings into clinical applications.

Original language	English (US)
Pages (from-to)	118-141
Number of pages	24
Journal	Annals of the New York Academy of Sciences
Volume	1506
Issue number	1
DOIs	https://doi.org/10.1111/nyas.14713
State	Published - Dec 2021

ASJC Scopus subject areas

General Neuroscience
General Biochemistry, Genetics and Molecular Biology
History and Philosophy of Science

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Cable, J., Heard, E., Hirose, T., Prasanth, K. V., Chen, L. L., Henninger, J. E., Quinodoz, S. A., Spector, D. L., Diermeier, S. D., Porman, A. M., Kumar, D., Feinberg, M. W., Shen, X., Unfried, J. P., Johnson, R., Chen, C. K., Wilusz, J. E., Lempradl, A., McGeary, S. E., ... Liu, X. (2021). Noncoding RNAs: biology and applications—a Keystone Symposia report. Annals of the New York Academy of Sciences, 1506(1), 118-141. https://doi.org/10.1111/nyas.14713

Cable, J, Heard, E, Hirose, T, Prasanth, KV, Chen, LL, Henninger, JE, Quinodoz, SA, Spector, DL, Diermeier, SD, Porman, AM, Kumar, D, Feinberg, MW, Shen, X, Unfried, JP, Johnson, R, Chen, CK, Wilusz, JE, Lempradl, A, McGeary, SE, Wahba, L, Pyle, AM, Hargrove, AE, Simon, MD, Marcia, M, Przanowska, RK, Chang, HY, Jaffrey, SR, Contreras, LM, Chen, Q, Shi, J, Mendell, JT, He, L, Song, E, Rinn, JL, Lalwani, MK, Kalem, MC, Chuong, EB, Maquat, LE & Liu, X 2021, 'Noncoding RNAs: biology and applications—a Keystone Symposia report', Annals of the New York Academy of Sciences, vol. 1506, no. 1, pp. 118-141. https://doi.org/10.1111/nyas.14713

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title = "Noncoding RNAs: biology and applications—a Keystone Symposia report",

abstract = "The human transcriptome contains many types of noncoding RNAs, which rival the number of protein-coding species. From long noncoding RNAs (lncRNAs) that are over 200 nucleotides long to piwi-interacting RNAs (piRNAs) of only 20 nucleotides, noncoding RNAs play important roles in regulating transcription, epigenetic modifications, translation, and cell signaling. Roles for noncoding RNAs in disease mechanisms are also being uncovered, and several species have been identified as potential drug targets. On May 11–14, 2021, the Keystone eSymposium “Noncoding RNAs: Biology and Applications” brought together researchers working in RNA biology, structure, and technologies to accelerate both the understanding of RNA basic biology and the translation of those findings into clinical applications.",

author = "Jennifer Cable and Edith Heard and Tetsuro Hirose and Prasanth, {Kannanganattu V.} and Chen, {Ling Ling} and Henninger, {Jonathan E.} and Quinodoz, {Sofia A.} and Spector, {David L.} and Diermeier, {Sarah D.} and Porman, {Allison M.} and Dhiraj Kumar and Feinberg, {Mark W.} and Xiaohua Shen and Unfried, {Juan Pablo} and Rory Johnson and Chen, {Chun Kan} and Wilusz, {Jeremy E.} and Adelheid Lempradl and McGeary, {Sean E.} and Lamia Wahba and Pyle, {Anna Marie} and Hargrove, {Amanda E.} and Simon, {Matthew D.} and Marco Marcia and Przanowska, {R{\'o}{\.z}a K.} and Chang, {Howard Y.} and Jaffrey, {Samie R.} and Contreras, {Lydia M.} and Qi Chen and Junchao Shi and Mendell, {Joshua T.} and Lin He and Erwei Song and Rinn, {John L.} and Lalwani, {Mukesh Kumar} and Kalem, {Murat Can} and Chuong, {Edward B.} and Maquat, {Lynne E.} and Xuhang Liu",

note = "Publisher Copyright: {\textcopyright} 2021 New York Academy of Sciences.",

year = "2021",

month = dec,

doi = "10.1111/nyas.14713",

language = "English (US)",

volume = "1506",

pages = "118--141",

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AU - Cable, Jennifer

AU - Heard, Edith

AU - Hirose, Tetsuro

AU - Prasanth, Kannanganattu V.

AU - Chen, Ling Ling

AU - Henninger, Jonathan E.

AU - Quinodoz, Sofia A.

AU - Spector, David L.

AU - Diermeier, Sarah D.

AU - Porman, Allison M.

AU - Kumar, Dhiraj

AU - Feinberg, Mark W.

AU - Shen, Xiaohua

AU - Unfried, Juan Pablo

AU - Johnson, Rory

AU - Chen, Chun Kan

AU - Wilusz, Jeremy E.

AU - Lempradl, Adelheid

AU - McGeary, Sean E.

AU - Wahba, Lamia

AU - Pyle, Anna Marie

AU - Hargrove, Amanda E.

AU - Simon, Matthew D.

AU - Marcia, Marco

AU - Przanowska, Róża K.

AU - Chang, Howard Y.

AU - Jaffrey, Samie R.

AU - Contreras, Lydia M.

AU - Chen, Qi

AU - Shi, Junchao

AU - Mendell, Joshua T.

AU - He, Lin

AU - Song, Erwei

AU - Rinn, John L.

AU - Lalwani, Mukesh Kumar

AU - Kalem, Murat Can

AU - Chuong, Edward B.

AU - Maquat, Lynne E.

AU - Liu, Xuhang

PY - 2021/12

Y1 - 2021/12

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AB - The human transcriptome contains many types of noncoding RNAs, which rival the number of protein-coding species. From long noncoding RNAs (lncRNAs) that are over 200 nucleotides long to piwi-interacting RNAs (piRNAs) of only 20 nucleotides, noncoding RNAs play important roles in regulating transcription, epigenetic modifications, translation, and cell signaling. Roles for noncoding RNAs in disease mechanisms are also being uncovered, and several species have been identified as potential drug targets. On May 11–14, 2021, the Keystone eSymposium “Noncoding RNAs: Biology and Applications” brought together researchers working in RNA biology, structure, and technologies to accelerate both the understanding of RNA basic biology and the translation of those findings into clinical applications.

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Noncoding RNAs: biology and applications—a Keystone Symposia report

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