Non-uraemic calciphylaxis successfully treated with pamidronate infusion

David H. Truong, Marcus M. Riedhammer, Kathya Zinszer

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Calciphylaxis is a rare and potentially fatal disease that affects the subcutaneous layer of the skin. It is a calcific vasculopathy induced by a systemic process that causes occlusion of small blood vessels. The mortality rate for individuals diagnosed with calciphylaxis is estimated between 52% and 81% with sepsis being the leading cause of death. Uraemic calciphylaxis and its known effective treatments are well documented in the literature. Unfortunately, there is no known effective treatment for non-uraemic calciphylaxis. Most of the current treatments for non-uraemic calciphylaxis are derived from uraemic calciphylaxis treatment protocols. We report a case of a 75-year-old female with calciphylaxis on the right lower extremity who was successfully treated with four pamidronate infusions in addition to local wound care. This case represents a non-uraemic calciphylaxis wound successfully treated with pamidronate infusions and standard wound care, and suggests that IV pamidronate can be an effective treatment option.

Original languageEnglish (US)
Pages (from-to)250-255
Number of pages6
JournalInternational Wound Journal
Issue number1
StatePublished - Feb 2019
Externally publishedYes


  • calcific arteriolopathy
  • leg ulcer
  • non-healing wound
  • sodium thiosulphate
  • vascular calcifications

ASJC Scopus subject areas

  • Surgery
  • Dermatology


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