Non-invasive neoplasia of the stomach

Massimo Rugge, Donato Nitti, Fabio Farinati, Francesco Di Mario, Robert M. Genta

Research output: Contribution to journalReview articlepeer-review

30 Scopus citations


Invasive gastric cancer is the final step of a cascade of genomic and phenotypic changes, which have been defined as multistep oncogenesis. This process includes a continuum of progressively dedifferentiated phenotypes, which may result in a biologically new (i.e., νε̇ω̇ = neo) cell characterized by autonomous, potentially metastatic, growth (i.e., πλαζω̇ = plasia). The clinico-pathological characterization of the advanced gastric precancerous lesions has important implications for both primary and secondary cancer prevention. The WHO agency has recently redefined dysplasia as intraepithelial [i.e., non-invasive neoplasia (NiN)]; such a proposal is consistent with the biological profile of dysplasia, which shares with invasive cancer some significant molecular attributes. Long-term follow-up studies have demonstrated that, in the natural history of gastric cancer, NiN precedes invasive adenocarcinoma. In this review, the morphological features of gastric NiN are described, also illustrating differences and similarities between the current and the previously adopted histological diagnostic criteria. The molecular profile of NiN is summarized and the spectrum of the options in the clinical management of gastric NiN are reported.

Original languageEnglish (US)
Pages (from-to)1191-1196
Number of pages6
JournalEuropean Journal of Gastroenterology and Hepatology
Issue number11
StatePublished - Nov 1 2005


  • Gastric dysplasia
  • Gastric non-invasive neoplasia
  • Gastric precancerous lesions

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology


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