TY - CHAP
T1 - Non-invasive intracranial pressure assessment in brain injured patients using ultrasound-based methods
AU - Robba, Chiara
AU - Cardim, Danilo
AU - Tajsic, Tamara
AU - Pietersen, Justine
AU - Bulman, Michael
AU - Rasulo, Frank
AU - Bertuetti, Rita
AU - Donnelly, Joseph
AU - Xiuyun, Liu
AU - Czosnyka, Zofia
AU - Cabeleira, Manuel
AU - Smielewski, Peter
AU - Matta, Basil
AU - Bertuccio, Alessandro
AU - Czosnyka, Marek
N1 - Publisher Copyright:
© Springer International Publishing AG 2018.
PY - 2018
Y1 - 2018
N2 - Background: Non-invasive measurement of intracranial pressure (ICP) can be invaluable in the management of critically ill patients. Invasive measurement of ICP remains the “gold standard” and should be performed when clinical indications are met, but it is invasive and brings some risks. In this project, we aim to validate the non-invasive ICP (nICP) assessment models based on arterious and venous transcranial Doppler ultrasonography (TCD) and optic nerve sheath diameter (ONSD). methods: We included brain injured patients requiring invasive ICP monitoring (intraparenchymal or intraventricular). We assessed the concordance between ICP measured non-invasively with arterious [flow velocity diastolic formula (ICPFVd) and pulsatility index (PI)], venous TCD (vPI) and ICP derived from ONSD (nICPONSD) compared to invasive ICP measurement. Results: Linear regression showed a positive relationship between nICP and ICP for all the methods, except PIv. ICPONSD showed the strongest correlation with invasive ICP (r = 0.61) compared to the other methods (ICPFVd, r = 0.26, p value = 0.0015; PI, r = 0.19, p value = 0.02, vPI, r = 0.056, p value = 0.510). The ability to predict intracranial hypertension was highest for ICPONSD (AUC = 0.91; 95% CI, 0.85–0.97 at ICP > 20 mmHg), with a sensitivity and specificity of 85%, followed by ICPFVd (AUC = 0.67; 95% CI, 0.54–0.79). Conclusions: Our results demonstrate that among the non-invasive methods studied, ONSD showed the best accuracy in the detection of ICP.
AB - Background: Non-invasive measurement of intracranial pressure (ICP) can be invaluable in the management of critically ill patients. Invasive measurement of ICP remains the “gold standard” and should be performed when clinical indications are met, but it is invasive and brings some risks. In this project, we aim to validate the non-invasive ICP (nICP) assessment models based on arterious and venous transcranial Doppler ultrasonography (TCD) and optic nerve sheath diameter (ONSD). methods: We included brain injured patients requiring invasive ICP monitoring (intraparenchymal or intraventricular). We assessed the concordance between ICP measured non-invasively with arterious [flow velocity diastolic formula (ICPFVd) and pulsatility index (PI)], venous TCD (vPI) and ICP derived from ONSD (nICPONSD) compared to invasive ICP measurement. Results: Linear regression showed a positive relationship between nICP and ICP for all the methods, except PIv. ICPONSD showed the strongest correlation with invasive ICP (r = 0.61) compared to the other methods (ICPFVd, r = 0.26, p value = 0.0015; PI, r = 0.19, p value = 0.02, vPI, r = 0.056, p value = 0.510). The ability to predict intracranial hypertension was highest for ICPONSD (AUC = 0.91; 95% CI, 0.85–0.97 at ICP > 20 mmHg), with a sensitivity and specificity of 85%, followed by ICPFVd (AUC = 0.67; 95% CI, 0.54–0.79). Conclusions: Our results demonstrate that among the non-invasive methods studied, ONSD showed the best accuracy in the detection of ICP.
KW - Brain ultrasound
KW - Intracranial pressure
KW - Optic nerve sheath diameter
KW - Transcranial doppler
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U2 - 10.1007/978-3-319-65798-1_15
DO - 10.1007/978-3-319-65798-1_15
M3 - Chapter
C2 - 29492535
AN - SCOPUS:85042925793
T3 - Acta Neurochirurgica, Supplementum
SP - 69
EP - 73
BT - Acta Neurochirurgica, Supplementum
PB - Springer-Verlag Wien
ER -