TY - JOUR
T1 - Non-fluent aphasia and neural reorganization after speech therapy
T2 - Insights from human sleep electrophysiology and functional magnetic resonance imaging
AU - Sarasso, S.
AU - Santhanam, P.
AU - Määtta, S.
AU - Poryazova, R.
AU - Ferrarelli, F.
AU - Tononi, G.
AU - Small, S. L.
PY - 2010
Y1 - 2010
N2 - Stroke is associated with long-term functional deficits. Behavioral interventions are often effective in promoting functional recovery and plastic changes. Recent studies in normal subjects have shown that sleep, and particularly slow wave activity (SWA), is tied to local brain plasticity and may be used as a sensitive marker of local cortical reorganization after stroke. In a pilot study, we assessed the local changes induced by a single exposure to a therapeutic session of IMITATE (Intensive Mouth Imitation and Talking for Aphasia Therapeutic Effects), a behavioral therapy used for recovery in patients with post-stroke aphasia. In addition, we measured brain activity changes with functional magnetic resonance imaging (fMRI) in a language observation task before, during and after the full IMITATE rehabilitative program. Speech production improved both after a single exposure and the full therapy program as measured by the Western Aphasia Battery (WAB) Repetition subscale. We found that IMITATE induced reorganization in functionally-connected, speech-relevant areas in the left hemisphere. These preliminary results suggest that sleep hd-EEGs, and the topographical analysis of SWA parameters, are well suited to investigate brain plastic changes underpinning functional recovery in neurological disorders.
AB - Stroke is associated with long-term functional deficits. Behavioral interventions are often effective in promoting functional recovery and plastic changes. Recent studies in normal subjects have shown that sleep, and particularly slow wave activity (SWA), is tied to local brain plasticity and may be used as a sensitive marker of local cortical reorganization after stroke. In a pilot study, we assessed the local changes induced by a single exposure to a therapeutic session of IMITATE (Intensive Mouth Imitation and Talking for Aphasia Therapeutic Effects), a behavioral therapy used for recovery in patients with post-stroke aphasia. In addition, we measured brain activity changes with functional magnetic resonance imaging (fMRI) in a language observation task before, during and after the full IMITATE rehabilitative program. Speech production improved both after a single exposure and the full therapy program as measured by the Western Aphasia Battery (WAB) Repetition subscale. We found that IMITATE induced reorganization in functionally-connected, speech-relevant areas in the left hemisphere. These preliminary results suggest that sleep hd-EEGs, and the topographical analysis of SWA parameters, are well suited to investigate brain plastic changes underpinning functional recovery in neurological disorders.
KW - EEG
KW - SWA
KW - Sleep
KW - Stroke rehabilitation
KW - fMRI
UR - http://www.scopus.com/inward/record.url?scp=78650492825&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78650492825&partnerID=8YFLogxK
M3 - Article
C2 - 21175013
AN - SCOPUS:78650492825
SN - 0003-9829
VL - 148
SP - 271
EP - 278
JO - Archives Italiennes de Biologie
JF - Archives Italiennes de Biologie
IS - 3
ER -