Non-epithelial tumors of the larynx: A single institution review

S. Karatayli-Ozgursoy, J. A. Bishop, A. T. Hillel, L. M. Akst, S. R. Best

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


Aim Non-epithelial tumors of the larynx are rare and encompass a wide range of pathology. We present the decade-long experience of a single institution to define clinical presentations and outcomes. Material and methods This is a ten year retrospective chart review of a tertiary head and neck cancer center. Index patients were identified from a review of a pathology database, and patient demographics, presenting signs and symptoms, treatment modalities, and clinical outcomes were extracted from electronic medical records. Epithelial tumors (squamous cell carcinoma, spindle cell carcinoma, and salivary tumors), granulomas, sarcoidosis, papilloma, and amyloidosis were all excluded. Results Twenty-four patients with ages ranging from 2 months-old to 84 years were identified. Malignant lesions (11) included chondrosarcoma (6), Kaposi's sarcoma (2), metastatic melanoma, synovial cell sarcoma, and T cell neoplasm. Six were operated upon endolaryngeally, but four required either upfront or salvage total laryngectomy. Two received adjuvant therapy. Benign lesions (13) included hemangioma (4), granular cell tumor (3), myofibroblastic tumor (2), schwannoma (2), chondroma, and ossifying fibromyxoid tumor. Nine underwent endolaryngeal operations, and four were managed medically or with observation. None have required aggressive open resection or total laryngectomy. Conclusion Treatment approach of non-epithelial tumors of the larynx depends on the site and extent of the tumor, histology, and sensitivity of adjuvant therapy. Benign tumors can be managed without need for aggressive resection thereby sparing laryngeal function.

Original languageEnglish (US)
Pages (from-to)279-285
Number of pages7
JournalAmerican Journal of Otolaryngology - Head and Neck Medicine and Surgery
Issue number3
StatePublished - May 1 2016

ASJC Scopus subject areas

  • Otorhinolaryngology


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