Non-Canonical Caspase Activity Antagonizes p38 MAPK Stress-Priming Function to Support Development

Benjamin P. Weaver; Yi M. Weaver; Shizue Omi; Wang Yuan; Jonathan J. Ewbank; Min Han

doi:10.1016/j.devcel.2020.03.015

Non-Canonical Caspase Activity Antagonizes p38 MAPK Stress-Priming Function to Support Development

Benjamin P. Weaver, Yi M. Weaver, Shizue Omi, Wang Yuan, Jonathan J. Ewbank, Min Han

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Weaver et al. describe a non-apoptotic role for CED-3 caspase during development in C. elegans. They show that a p38 MAPK pathway primes animals for stressful encounters by upregulating stress-responsive genes and slowing development. CED-3 antagonizes this stress response via proteolytic inactivation of p38, thus promoting development.

Original language	English (US)
Pages (from-to)	358-369.e6
Journal	Developmental cell
Volume	53
Issue number	3
DOIs	https://doi.org/10.1016/j.devcel.2020.03.015
State	Published - May 4 2020

Keywords

DUSP
NLP-29
VHP-1
innate immunity
kinase
metabolism
non-apoptotic
phosphatase
proteostasis
translation

ASJC Scopus subject areas

Molecular Biology
General Biochemistry, Genetics and Molecular Biology
Developmental Biology
Cell Biology

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10.1016/j.devcel.2020.03.015

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title = "Non-Canonical Caspase Activity Antagonizes p38 MAPK Stress-Priming Function to Support Development",

abstract = "Weaver et al. describe a non-apoptotic role for CED-3 caspase during development in C. elegans. They show that a p38 MAPK pathway primes animals for stressful encounters by upregulating stress-responsive genes and slowing development. CED-3 antagonizes this stress response via proteolytic inactivation of p38, thus promoting development.",

keywords = "DUSP, NLP-29, VHP-1, innate immunity, kinase, metabolism, non-apoptotic, phosphatase, proteostasis, translation",

author = "Weaver, {Benjamin P.} and Weaver, {Yi M.} and Shizue Omi and Wang Yuan and Ewbank, {Jonathan J.} and Min Han",

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doi = "10.1016/j.devcel.2020.03.015",

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AU - Weaver, Benjamin P.

AU - Weaver, Yi M.

AU - Omi, Shizue

AU - Yuan, Wang

AU - Ewbank, Jonathan J.

AU - Han, Min

PY - 2020/5/4

Y1 - 2020/5/4

N2 - Weaver et al. describe a non-apoptotic role for CED-3 caspase during development in C. elegans. They show that a p38 MAPK pathway primes animals for stressful encounters by upregulating stress-responsive genes and slowing development. CED-3 antagonizes this stress response via proteolytic inactivation of p38, thus promoting development.

AB - Weaver et al. describe a non-apoptotic role for CED-3 caspase during development in C. elegans. They show that a p38 MAPK pathway primes animals for stressful encounters by upregulating stress-responsive genes and slowing development. CED-3 antagonizes this stress response via proteolytic inactivation of p38, thus promoting development.

KW - DUSP

KW - NLP-29

KW - VHP-1

KW - innate immunity

KW - kinase

KW - metabolism

KW - non-apoptotic

KW - phosphatase

KW - proteostasis

KW - translation

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JO - Developmental cell

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ER -

Non-Canonical Caspase Activity Antagonizes p38 MAPK Stress-Priming Function to Support Development

Abstract

Keywords

ASJC Scopus subject areas

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