Nitric oxide-induced nitrative stress involved in microbial pathogenesis

Mohammad Hasan Zaki, Teruo Akuta, Takaaki Akaike

Research output: Contribution to journalReview articlepeer-review

102 Scopus citations


The pathogenic mechanism of infections is a complicated but important scientific theme that is now attracting great attention because of its association with host-derived as well as microbial factors. Recent advances in free radical research revealed that reactive oxygen and nitrogen oxide species such as superoxide (O2-) and nitric oxide (NO) play a leading role in the pathogenesis of infections caused by viral pathogens including influenza virus and other RNA viruses. Although NO and O 2- have antimicrobial activity against bacteria, fungi, and parasites, in some viral infections they have an opposite effect. This exacerbation caused by NO and O2- is mediated by reactive nitrogen oxides, for example, peroxynitrite (ONOO-), generated by reaction of NO with O2-. These nitrogen oxides have strong oxidation and nitration potential and can modify biological molecules, thereby creating oxidative and nitrative stress that contributes to pathogenic processes during viral infection. Nitrative stress-mediated 8-nitroguanosine formation during influenza or Sendai virus infection has been the focus of enormous interest because it involves unique biochemical and pharmacological properties such as redox activity and mutagenic potential. In this review, we discuss the nature and impact of nitrative stress in viral infection, with emphasis on nitrative stress-mediated viral pathogenesis, which we have recently been investigating.

Original languageEnglish (US)
Pages (from-to)117-129
Number of pages13
JournalJournal of Pharmacological Sciences
Issue number2
StatePublished - Jun 2005


  • 8-nitroguanosine
  • Nitrative stress
  • Nitric oxide
  • Peroxynitrite
  • Viral mutation
  • Viral pathogenesis

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology


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