NHX-5, Anl endosomal Na+/H+ exchanger, is associated with metformin action

Jeongho Kim, Hye Yeon Lee, Jheesoo Ahn, Moonjung Hyun, Inhwan Lee, Kyung Jin Min, Young Jai You

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Diabetes is one of the most impactful diseases worldwide. The most commonly prescribed anti-diabetic drug is metformin. In this study, we identified an endosomal Na+/H+ exchanger (NHE) as a new potential target of metformin from an unbiased screen in Caenorhabditis elegans. The same NHE homolog also exists in flies, where it too mediates the effects of metformin. Our results suggest that endosomal NHEs could be a metformin target and provide an insight into a novel mechanism of action of metformin on regulating the endocytic cycle.

Original languageEnglish (US)
Pages (from-to)18591-18599
Number of pages9
JournalJournal of Biological Chemistry
Issue number35
StatePublished - Aug 26 2016
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology


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