NG2 glia reprogramming induces robust axonal regeneration after spinal cord injury

Wenjiao Tai, Xiaolong Du, Chen Chen, Xiao Ming Xu, Chun Li Zhang, Wei Wu

Research output: Contribution to journalArticlepeer-review

Abstract

Spinal cord injury (SCI) often leads to neuronal loss, axonal degeneration, and behavioral dysfunction. We recently show that in vivo reprogramming of NG2 glia produces new neurons, reduces glial scaring, and ultimately leads to improved function after SCI. By examining endogenous neurons, we here unexpectedly uncover that NG2 glia reprogramming also induces robust axonal regeneration of the corticospinal tract and serotonergic neurons. Such reprogramming-induced axonal regeneration may contribute to the reconstruction of neural networks essential for behavioral recovery.

Original languageEnglish (US)
Article number108895
JournaliScience
Volume27
Issue number2
DOIs
StatePublished - Feb 16 2024

Keywords

  • Cell biology
  • Molecular biology
  • Neuroscience

ASJC Scopus subject areas

  • General

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