New molecularly targeted therapies for lung cancer

Sophie Sun, Joan H. Schiller, Monica Spinola, John D. Minna

Research output: Contribution to journalReview articlepeer-review

169 Scopus citations


Lung cancer is the leading cause of cancer death worldwide. The disease is particularly difficult to detect, and patients often present at an advanced stage. Current treatments have limited effectiveness, and unfortunately, the prognosis remains poor. Recent insights into the molecular pathogenesis and biologic behavior of lung cancer have led to the development of rationally designed methods of early detection, prevention, and treatment of this disease. This article will review the important clinical implications of these advances, with a focus on new molecularly targeted therapies currently in development.

Original languageEnglish (US)
Pages (from-to)2740-2750
Number of pages11
JournalJournal of Clinical Investigation
Issue number10
StatePublished - Oct 1 2007

ASJC Scopus subject areas

  • Medicine(all)


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