New Insights in the Pathophysiology of Antiphospholipid Syndrome

Anastasia Sacharidou, Philip W. Shaul, Chieko Mineo

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


The antiphospholipid syndrome (APS) is an autoimmune disorder characterized by an elevated risk for arterial and venous thrombosis and pregnancy-related morbidity. Since the discovery of the disease in 1980s, numerous studies in cell culture systems, in animal models, and in patient populations have been reported, leading to a deeper understanding of the pathogenesis of APS. These studies have determined that circulating autoantibodies, collectively called antiphospholipid antibodies (aPL), the majority of which recognize cell surface proteins attached to the plasma membrane phospholipids, play a causal role in the development of the disease. The binding of aPL to the cell surface antigens triggers interaction of the complex with transmembrane receptors to initiate intracellular signaling in critical cell types, including platelets, monocytes, endothelial cells, and trophoblasts. Subsequent alteration of various cell functions results in inflammation, thrombus formation, and pregnancy complications. Apolipoprotein E receptor 2 (apoER2), a lipoprotein receptor family member, has been implicated as a mediator for aPL actions in platelets and endothelial cells. Nitric oxide (NO) is a signaling molecule known to exert potent antithrombotic, anti-inflammatory, and anti-atherogenic effects. NO insufficiency and oxidative stress have been linked to APS pathogenesis. This review will focus on the recent findings on how apoER2 and dysregulation of NO production contribute to aPL-mediated pathologies in APS.

Original languageEnglish (US)
Pages (from-to)475-482
Number of pages8
JournalSeminars in Thrombosis and Hemostasis
Issue number5
StatePublished - Jul 1 2018


  • antiphospholipid syndrome
  • apoE receptor 2
  • endothelium
  • nitric oxide synthase
  • trophoblast

ASJC Scopus subject areas

  • Hematology
  • Cardiology and Cardiovascular Medicine


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