Neutrophils accumulate and contribute to skeletal muscle dysfunction after ischemia-reperfusion

D. L. Walden, H. McCutchan, E. G. Enquist, J. R. Schwappach, P. F. Shanley, O. K. Reiss, L. S. Terada, J. A. Leff, J. E. Repine

Research output: Contribution to journalArticlepeer-review

49 Scopus citations


Skeletal muscles subjected to ischemia and then reperfusion develop contractile dysfunction for reasons that are unclear. We found that rats pretreated with vinblastine 4 days before study had decreased numbers of blood neutrophils and increased gastrocnemius muscle function after ischemia (3 h) and reperfusion (4 h) compared with untreated rats or rats treated 4 days before study with saline. By comparison, rats pretreated with vinblastine or saline 1 day before study had increased blood neutrophils and decreased gastrocnemius muscle contractile function after ischemia-reperfusion compared with untreated rats. In addition, numbers of neutrophils in gastrocnemius muscles paralleled numbers of blood neutrophils and correlated with gastrocnemius muscle edema and contractile function after ischemia and reperfusion. The results indicate that neutrophils accumulate and may play an important role in the genesis of skeletal muscle contractile dysfunction after ischemia-reperfusion.

Original languageEnglish (US)
Pages (from-to)H1809-H1812
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Issue number6 28-6
StatePublished - Jan 1 1990


  • blood neutrophils
  • vinblastine

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)


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