Neurosyphilis Update: Atypical is the New Typical

Salman Bhai, Jennifer L. Lyons

Research output: Contribution to journalReview articlepeer-review

40 Scopus citations


Syphilis has reemerged as an important cause of neurological disease, affecting any part of the neuraxis at any stage of infection. What was once a dwindling diagnosis is now redoubling, particularly in the HIV-positive and in men who have sex with men populations. In the era of antibiotics and HIV coinfection, neurosyphilis presentations are protean, making diagnosis notoriously challenging. Advanced disease may be irreversible, and so early detection and treatment are ideal. Herein, we review recent advances in understanding neurosyphilis.

Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalCurrent Infectious Disease Reports
Issue number5
StatePublished - May 1 2015
Externally publishedYes


  • Dementia
  • HIV
  • Neuroinfectious diseases
  • Neurosyphilis
  • Syphilis

ASJC Scopus subject areas

  • Infectious Diseases


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