Neuropsychological outcome following unilateral stereotactic pallidotomy in intractable Parkinson's disease

Laura H. Lacritz, C. Munro Cullum, Alan B. Frol, Richard B. Dewey, Cole A. Giller

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


Neuropsychological functioning was examined at baseline and 2- to 3- month follow-up in 40 subjects with advanced Parkinson's disease (PD) who underwent unilateral posteroventral pallidotomy. Most subjects demonstrated improved verbal learning, visual memory, confrontation naming, and figural fluency at follow-up. Right pallidotomy was associated with decreased cognitive flexibility and increased verbal fluency, whereas Left pallidotomy uniquely resulted in a decline in verbal fluency. Significant motor improvement was demonstrated in both groups. Pallidotomy appears to be an effective treatment for advanced PD, providing a significant improvement in motor functioning, while resulting in few deleterious neurocognitive changes in most cases. (C) 2000 Academic Press.

Original languageEnglish (US)
Pages (from-to)364-378
Number of pages15
JournalBrain and Cognition
Issue number3
StatePublished - Apr 2000

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Experimental and Cognitive Psychology
  • Developmental and Educational Psychology
  • Arts and Humanities (miscellaneous)
  • Cognitive Neuroscience


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