Neuroprotection in acute brain injury: An up-to-date review

Nino Stocchetti; Fabio S. Taccone; Giuseppe Citerio; Paul E. Pepe; Peter D. Roux; Mauro Oddo; Kees H. Polderman; Robert D. Stevens; William Barsan; Andrew I R Maas; Geert Meyfroidt; Michael J. Bell; Robert Silbergleit; Paul M. Vespa; Alan I. Faden; Raimund Helbok; Samuel Tisherman; Elisa R. Zanier; Terence Valenzuela; Julia Wendon; David K. Menon; Jean Louis Vincent

doi:10.1186/s13054-015-0887-8

Neuroprotection in acute brain injury: An up-to-date review

Nino Stocchetti, Fabio S. Taccone, Giuseppe Citerio, Paul E. Pepe, Peter D. Roux, Mauro Oddo, Kees H. Polderman, Robert D. Stevens, William Barsan, Andrew I R Maas, Geert Meyfroidt, Michael J. Bell, Robert Silbergleit, Paul M. Vespa, Alan I. Faden, Raimund Helbok, Samuel Tisherman, Elisa R. Zanier, Terence Valenzuela, Julia WendonDavid K. Menon, Jean Louis Vincent

Research output: Contribution to journal › Review article › peer-review

110 Scopus citations

Abstract

Neuroprotective strategies that limit secondary tissue loss and/or improve functional outcomes have been identified in multiple animal models of ischemic, hemorrhagic, traumatic and nontraumatic cerebral lesions. However, use of these potential interventions in human randomized controlled studies has generally given disappointing results. In this paper, we summarize the current status in terms of neuroprotective strategies, both in the immediate and later stages of acute brain injury in adults. We also review potential new strategies and highlight areas for future research.

Original language	English (US)
Article number	186
Journal	Critical Care
Volume	19
Issue number	1
DOIs	https://doi.org/10.1186/s13054-015-0887-8
State	Published - Apr 21 2015

ASJC Scopus subject areas

Critical Care and Intensive Care Medicine

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Stocchetti, N., Taccone, F. S., Citerio, G., Pepe, P. E., Roux, P. D., Oddo, M., Polderman, K. H., Stevens, R. D., Barsan, W., Maas, A. I. R., Meyfroidt, G., Bell, M. J., Silbergleit, R., Vespa, P. M., Faden, A. I., Helbok, R., Tisherman, S., Zanier, E. R., Valenzuela, T., ... Vincent, J. L. (2015). Neuroprotection in acute brain injury: An up-to-date review. Critical Care, 19(1), Article 186. https://doi.org/10.1186/s13054-015-0887-8

Stocchetti, N, Taccone, FS, Citerio, G, Pepe, PE, Roux, PD, Oddo, M, Polderman, KH, Stevens, RD, Barsan, W, Maas, AIR, Meyfroidt, G, Bell, MJ, Silbergleit, R, Vespa, PM, Faden, AI, Helbok, R, Tisherman, S, Zanier, ER, Valenzuela, T, Wendon, J, Menon, DK & Vincent, JL 2015, 'Neuroprotection in acute brain injury: An up-to-date review', Critical Care, vol. 19, no. 1, 186. https://doi.org/10.1186/s13054-015-0887-8

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abstract = "Neuroprotective strategies that limit secondary tissue loss and/or improve functional outcomes have been identified in multiple animal models of ischemic, hemorrhagic, traumatic and nontraumatic cerebral lesions. However, use of these potential interventions in human randomized controlled studies has generally given disappointing results. In this paper, we summarize the current status in terms of neuroprotective strategies, both in the immediate and later stages of acute brain injury in adults. We also review potential new strategies and highlight areas for future research.",

author = "Nino Stocchetti and Taccone, {Fabio S.} and Giuseppe Citerio and Pepe, {Paul E.} and Roux, {Peter D.} and Mauro Oddo and Polderman, {Kees H.} and Stevens, {Robert D.} and William Barsan and Maas, {Andrew I R} and Geert Meyfroidt and Bell, {Michael J.} and Robert Silbergleit and Vespa, {Paul M.} and Faden, {Alan I.} and Raimund Helbok and Samuel Tisherman and Zanier, {Elisa R.} and Terence Valenzuela and Julia Wendon and Menon, {David K.} and Vincent, {Jean Louis}",

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AU - Roux, Peter D.

AU - Oddo, Mauro

AU - Polderman, Kees H.

AU - Stevens, Robert D.

AU - Barsan, William

AU - Maas, Andrew I R

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AU - Bell, Michael J.

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AU - Faden, Alan I.

AU - Helbok, Raimund

AU - Tisherman, Samuel

AU - Zanier, Elisa R.

AU - Valenzuela, Terence

AU - Wendon, Julia

AU - Menon, David K.

AU - Vincent, Jean Louis

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AB - Neuroprotective strategies that limit secondary tissue loss and/or improve functional outcomes have been identified in multiple animal models of ischemic, hemorrhagic, traumatic and nontraumatic cerebral lesions. However, use of these potential interventions in human randomized controlled studies has generally given disappointing results. In this paper, we summarize the current status in terms of neuroprotective strategies, both in the immediate and later stages of acute brain injury in adults. We also review potential new strategies and highlight areas for future research.

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Neuroprotection in acute brain injury: An up-to-date review

Abstract

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