Neuropathological changes in essential tremor: 33 Cases compared with 21 controls

Elan D. Louis, Phyllis L. Faust, Jean Paul G. Vonsattel, Lawrence S. Honig, Alex Rajput, Christopher A. Robinson, Ali Rajput, Rajesh Pahwa, Kelly E. Lyons, G. Webster Ross, Sarah Borden, Carol B. Moskowitz, Arlene Lawton, Nora Hernandez

Research output: Contribution to journalArticlepeer-review

457 Scopus citations


Despite its being one of the most commonly observed neurological disorders, neuropathological studies of essential tremor (ET) are rare. There have been surprisingly few autopsy studies and even fewer case-control comparisons. The primary objective was to describe and quantify the pathological changes in 33 ET and 21 control brains. A secondary objective was to correlate clinical and pathological features. We examined autopsy tissue from the Essential Tremor Centralized Brain Repository. Eight (24.2%) of the 33 ET brains had Lewy bodies in the brainstem, mainly in the locus ceruleus. However, the majority of ET brains (25/33, 75.8%) had no Lewy bodies, but had pathological changes in the cerebellum. The mean number of Purkinje cells per 100× field was reduced in ET cases without Lewy bodies (6.6 ± 2.4 versus 9.6 ± 3.4, P < 0.01), and there were ∼7× more Purkinje cell torpedoes per section (12.6 ± 7.9 versus 1.7 ± 1.4, P < 0.001) compared to controls. ET cases without Lewy bodies also had degeneration of the dentate nucleus (two cases). Other findings in ET cases were Purkinje cell heterotopias and dendrite swellings. Lewy body ET cases were older than ET cases without Lewy bodies. Several trends were observed in ET cases without Lewy bodies, including a younger age of onset of tremor and higher proportions with gait difficulty and family history of ET. The pathological changes of ET seem to be heterogeneous and degenerative. The majority have cerebellar changes without Lewy bodies; a smaller proportion has brainstem Lewy bodies. The clinical differences between cases with versus without Lewy bodies require additional study.

Original languageEnglish (US)
Pages (from-to)3297-3307
Number of pages11
Issue number12
StatePublished - Dec 2007
Externally publishedYes


  • Cerebellum
  • Essential tremor
  • Lewy body
  • Locus ceruleus
  • Neurodegeneration
  • Purkinje cell

ASJC Scopus subject areas

  • Clinical Neurology


Dive into the research topics of 'Neuropathological changes in essential tremor: 33 Cases compared with 21 controls'. Together they form a unique fingerprint.

Cite this