TY - JOUR
T1 - Neuromodulation for mood and memory
T2 - From the engineering bench to the patient bedside
AU - Deng, Zhi De
AU - McClintock, Shawn M.
AU - Oey, Nicodemus E.
AU - Luber, Bruce
AU - Lisanby, Sarah H.
N1 - Funding Information:
Dr. Deng is an inventor on patents and patent applications related to TMS coil technology. Dr. Lisanby is an inventor on patents and patent applications related to TMS coil technology and ECT dosing procedure. Dr. Lisanby has served as Principal Investigator on industry-sponsored research grants to Columbia/RFMH or Duke (Neuronetics (past), Brainsway, ANS/St. Jude Medical (past), Cyberonics (past)); equipment loans to Columbia or Duke (Magstim, MagVenture); is supported by grants from NIH ( R01MH091083-01 , 5U01MH084241-02 , 5R01MH060884-09 ), Stanley Medical Research Institute, National Alliance for Research on Schizophrenia and Depression, and the Wallace H. Coulter Foundation; and has no consultancies, speakers bureau memberships, board affiliations, or equity holdings in related industries. Drs. McClintock and Luber, and Mr. Oey have no conflicts of interest to declare.
Funding Information:
This manuscript was supported in part by grants from the National Institutes of Health/National Center for Advancing Translational Sciences (KL2 TR001115-02 ), and National Institute of Mental Health ( K23 MH087739 ).
Publisher Copyright:
© 2014 Elsevier B.V.
PY - 2015/2/1
Y1 - 2015/2/1
N2 - Brain stimulation, in the form of electroconvulsive therapy (ECT), has long been a gold standard treatment for depression, but today, the field of neuromodulation is rapidly changing with the advent of newer and more precise tools to alter neuroplasticity and to treat brain-based disorders. Now there are new means to induce focal seizures, as with magnetic seizure therapy (MST), or modifications to ECT. There are also surgical approaches to target brain circuits via implanted stimulators placed in the brain or on cranial nerves. Finally, there are noninvasive subconvulsive approaches for the transcranial application of either electric or magnetic fields. Collectively, these tools have transformed the face of neurotherapeutics and informed our understanding of the brain basis of complex neurobehavioral conditions.
AB - Brain stimulation, in the form of electroconvulsive therapy (ECT), has long been a gold standard treatment for depression, but today, the field of neuromodulation is rapidly changing with the advent of newer and more precise tools to alter neuroplasticity and to treat brain-based disorders. Now there are new means to induce focal seizures, as with magnetic seizure therapy (MST), or modifications to ECT. There are also surgical approaches to target brain circuits via implanted stimulators placed in the brain or on cranial nerves. Finally, there are noninvasive subconvulsive approaches for the transcranial application of either electric or magnetic fields. Collectively, these tools have transformed the face of neurotherapeutics and informed our understanding of the brain basis of complex neurobehavioral conditions.
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U2 - 10.1016/j.conb.2014.08.015
DO - 10.1016/j.conb.2014.08.015
M3 - Review article
C2 - 25222617
AN - SCOPUS:84907546208
SN - 0959-4388
VL - 30
SP - 38
EP - 43
JO - Current Opinion in Neurobiology
JF - Current Opinion in Neurobiology
ER -