Neuromodulation for mood and memory: From the engineering bench to the patient bedside

Zhi De Deng, Shawn M. McClintock, Nicodemus E. Oey, Bruce Luber, Sarah H. Lisanby

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations


Brain stimulation, in the form of electroconvulsive therapy (ECT), has long been a gold standard treatment for depression, but today, the field of neuromodulation is rapidly changing with the advent of newer and more precise tools to alter neuroplasticity and to treat brain-based disorders. Now there are new means to induce focal seizures, as with magnetic seizure therapy (MST), or modifications to ECT. There are also surgical approaches to target brain circuits via implanted stimulators placed in the brain or on cranial nerves. Finally, there are noninvasive subconvulsive approaches for the transcranial application of either electric or magnetic fields. Collectively, these tools have transformed the face of neurotherapeutics and informed our understanding of the brain basis of complex neurobehavioral conditions.

Original languageEnglish (US)
Pages (from-to)38-43
Number of pages6
JournalCurrent Opinion in Neurobiology
StatePublished - Feb 1 2015

ASJC Scopus subject areas

  • Neuroscience(all)


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