TY - JOUR
T1 - Neurological injury in pediatric heart disease
T2 - A review of developmental and acquired risk factors and management considerations
AU - McGetrick, Molly E.
AU - Riviello, James J.
N1 - Publisher Copyright:
© 2024
PY - 2024
Y1 - 2024
N2 - Medical and surgical advancements have improved survival in children with acquired and congenital heart disease (CHD), but the burden of neurological morbidity is high. Brain disorders associated with CHD include white matter injury, stroke, seizure, and neurodevelopmental delays. While genetics and disease-specific factors play a substantial role in early brain injury, therapeutic management of the heart disease intensifies the risk. There is a growing interest in understanding how to reduce brain injury and improve neurodevelopmental outcomes in cardiac diseases. Pediatric neurologists serve a vital role in care teams managing these complex patients, providing interpretation of neuromonitoring and imaging, managing neurologic emergencies, assisting with neuro prognostication, and identifying future research aims.
AB - Medical and surgical advancements have improved survival in children with acquired and congenital heart disease (CHD), but the burden of neurological morbidity is high. Brain disorders associated with CHD include white matter injury, stroke, seizure, and neurodevelopmental delays. While genetics and disease-specific factors play a substantial role in early brain injury, therapeutic management of the heart disease intensifies the risk. There is a growing interest in understanding how to reduce brain injury and improve neurodevelopmental outcomes in cardiac diseases. Pediatric neurologists serve a vital role in care teams managing these complex patients, providing interpretation of neuromonitoring and imaging, managing neurologic emergencies, assisting with neuro prognostication, and identifying future research aims.
KW - congenital heart disease
KW - heart failure
KW - Mechanical Circulatory Support
KW - seizure
KW - stroke
KW - ventricular assist device
UR - http://www.scopus.com/inward/record.url?scp=85184012270&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85184012270&partnerID=8YFLogxK
U2 - 10.1016/j.spen.2024.101115
DO - 10.1016/j.spen.2024.101115
M3 - Article
AN - SCOPUS:85184012270
SN - 1071-9091
JO - Seminars in Pediatric Neurology
JF - Seminars in Pediatric Neurology
M1 - 101115
ER -