Neurogenic inflammation in cholecystitis

Jay B. Prystowsky, Robert V Rege

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Neurogenic inflammation implies stimulation of nerves with resultant inflammation in tissue surrounding the nerve terminals. We hypothesized that neurogenic inflammation has a role in cholecystitis. Capsaicin (stimulant of afferent, nociceptive neurons), 6-hydroxydopamine (stimulates release of peptides from sympathetic nerve terminals), bradykinin, lipopolysaccharide, and saline were instilled into guinea pig gallbladders for 24 hr (N = 5 in each group). In parallel, test agents were instilled with 1% lidocaine. Water transport across gallbladder mucosa, myeloperoxidase and interleukin-1 release from gallbladder tissue, and prostaglandin E2 in luminal fluid were measured. Capsaicin caused water secretion and significant release of myeloperoxidase, interleukin-1, and prostaglandin-E2, effects that were blocked by lidocaine. 6-Hydroxydopamine did not affect water transport or prostaglandin E2, but did cause myeloperoxidase and interleukin-1 release. Bradykinin- and lipopolysaccharide-induced inflammation were partially inhibited by lidocaine. Taken together, these results suggest that neurogenic inflammation has a role in the pathophysiology of cholecystitis.

Original languageEnglish (US)
Pages (from-to)1489-1494
Number of pages6
JournalDigestive Diseases and Sciences
Issue number7
StatePublished - 1997


  • Capsaicin
  • Cholecystitis
  • Gallbladder
  • Neurogenic inflammation
  • Nociception

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology


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