Neurogenesis or Neuronal Specification: Phosphorylation Strikes Again!

Helen C. Lai; Jane E. Johnson

doi:10.1016/j.neuron.2008.03.023

Neurogenesis or Neuronal Specification: Phosphorylation Strikes Again!

Helen C. Lai, Jane E. Johnson

Research output: Contribution to journal › Short survey › peer-review

4 Scopus citations

Abstract

How basic helix-loop-helix (bHLH) transcription factors control neurogenesis and neuronal subtype specification through transcriptional mechanisms mediated by cell signaling remains to be fully elucidated. In this issue of Neuron, Ma et al. discover that phosphorylation via GSK3 of the bHLH factor, Ngn2 (Neurog2), adds a neuronal subtype-specific program to its functional repertoire that is activated in the developing neural tube in vivo.

Original language	English (US)
Pages (from-to)	3-5
Number of pages	3
Journal	Neuron
Volume	58
Issue number	1
DOIs	https://doi.org/10.1016/j.neuron.2008.03.023
State	Published - Apr 10 2008

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/j.neuron.2008.03.023

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abstract = "How basic helix-loop-helix (bHLH) transcription factors control neurogenesis and neuronal subtype specification through transcriptional mechanisms mediated by cell signaling remains to be fully elucidated. In this issue of Neuron, Ma et al. discover that phosphorylation via GSK3 of the bHLH factor, Ngn2 (Neurog2), adds a neuronal subtype-specific program to its functional repertoire that is activated in the developing neural tube in vivo.",

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Neurogenesis or Neuronal Specification: Phosphorylation Strikes Again!

Abstract

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