Neuregulin 1-HER axis as a key mediator of hyperglycemic memory effects in breast cancer

Jiyoung Park, Venetia R. Sarode, David Euhus, Ralf Kittler, Philipp E. Scherer

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


Poor outcomes in diabetic patients are observed across a range of human tumors, suggesting that cancer cells develop unique characteristics under diabetic conditions. Cancer cells exposed to hyperglycemic insults acquire permanent aggressive traits of tumor growth, even after a return to euglycemic conditions. Comparative genome-wide mapping of hyperglycemia-specific open chromatin regions and concomitant mRNA expression profiling revealed that the neuregulin-1 gene, encoding an established endogenous ligand for the HER3 receptor, is activated through a putative distal enhancer. Our findings highlight the targeted inhibition of NRG1-HER3 pathways as a potential target for the treatment breast cancer patients with associated diabetes.

Original languageEnglish (US)
Pages (from-to)21058-21063
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number51
StatePublished - Dec 18 2012


  • FAIRE-seq
  • Metabolic imprinting

ASJC Scopus subject areas

  • General


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