TY - GEN
T1 - Neural plasticity and functional recovery following cortical ischemie injury
AU - Plautz, Erik J.
AU - Nudo, Randolph J.
PY - 2005
Y1 - 2005
N2 - Stroke is a leading cause of persistent motor disability, but few effective treatments exist for application at chronic post-injury timepoints. An approach that combines rehabilitative training with cortical electrical stimulation was evaluated in a non-human primate model of cortical ischemic stroke. Results indicate that cortical stimulation plus rehabilitation enhanced motor recovery compared to rehabilitation alone. Functional mapping of the spared, peri-infarct motor cortex revealed expansions of motor representations related to the rehabilitative task, with greater expansions for subjects that underwent the combined therapy. It is concluded that electrical stimulation combined with rehabilitation enhanced plastic reorganization of the affected motor cortex, leading to superior behavioral recovery.
AB - Stroke is a leading cause of persistent motor disability, but few effective treatments exist for application at chronic post-injury timepoints. An approach that combines rehabilitative training with cortical electrical stimulation was evaluated in a non-human primate model of cortical ischemic stroke. Results indicate that cortical stimulation plus rehabilitation enhanced motor recovery compared to rehabilitation alone. Functional mapping of the spared, peri-infarct motor cortex revealed expansions of motor representations related to the rehabilitative task, with greater expansions for subjects that underwent the combined therapy. It is concluded that electrical stimulation combined with rehabilitation enhanced plastic reorganization of the affected motor cortex, leading to superior behavioral recovery.
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M3 - Conference contribution
AN - SCOPUS:33846923366
SN - 0780387406
SN - 9780780387409
T3 - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
SP - 4145
EP - 4148
BT - Proceedings of the 2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005
T2 - 2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005
Y2 - 1 September 2005 through 4 September 2005
ER -