Abstract
Objective: To explore the relationship between neonatal oxygen saturation and BP at age 6–7 years in a cohort of infants born extremely preterm. Study design: Infants <28 weeks gestation were assigned to a higher or lower oxygen saturation target. Oximeter data were monitored throughout the neonatal period. A subset of survivors was seen at age 6. BP was measured and compared by group assignment, achieved saturations, and time spent in hypoxemia (saturations <80%). Results: There was no difference in systolic or diastolic BP between assigned groups. Median achieved weekly oxygen saturation was not associated with BP. Longer duration of hypoxemia during the first week of age was associated with higher systolic BP. Conclusions: Neither target nor actual median oxygen saturations in this study was associated with BP at school age. Increased duration of hypoxemia in the first postnatal week was associated with higher systolic BP at 6–7 years of age.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 902-908 |
| Number of pages | 7 |
| Journal | Journal of Perinatology |
| Volume | 40 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jun 1 2020 |
| Externally published | Yes |
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Obstetrics and Gynecology
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In: Journal of Perinatology, Vol. 40, No. 6, 01.06.2020, p. 902-908.
Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Neonatal oxygen saturations and blood pressure at school-age in children born extremely preterm
T2 - a cohort study
AU - For the Eunice Kennedy Shrive National Institute of Child Health and Human Development Neonatal Research Network
AU - Oren, Marina S.
AU - Ianus, Vlad
AU - Vohr, Betty R.
AU - Hintz, Susan R.
AU - Do, Barbara T.
AU - Das, Abhik
AU - Shankaran, Seetha
AU - Higgins, Rosemary D.
AU - Watterberg, Kristi L.
N1 - Funding Information: Funding The National Institutes of Health (M01 RR30, M01 RR32, M01 RR39, M01 RR54, M01 RR59, M01 RR64, M01 RR80, M01 RR70, M01 RR633, M01 RR750, M01 RR997, UL1 RR25008, UL1 RR25744, UL1 TR442), the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (U10 HD21364, U10 HD21385, U10 HD21373, U10 HD27851, U10 HD27856, U10 HD27880, U10 HD27904, U10 HD34216, U10 HD36790, U10 HD40461, U10 HD40492, U10 HD40689, U10 HD53089, U10 HD53109, U10 HD53119, U10 HD53124), and the National Heart, Lung, and Blood Institute (NHLBI) (via co-funding) provided grant support for the NRN’s Extended follow-up at School Age for the SUPPORT NEURO Cohort. Funding Information: Acknowledgements The National Institutes of Health, the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), and the National Heart, Lung, and Blood Institute (NHLBI) provided grant support for the Neonatal Research Network’s Extended Follow-up at School Age for the SUPPORT Neuroimaging and Neurodevelopmental Outcomes (NEURO) Cohort through cooperative agreements. While NICHD staff had input into the study design, conduct, analysis, and manuscript drafting, the comments and views of the authors do not necessarily represent the views of the NICHD. Data collected at participating sites of the NICHD Neonatal Research Network (NRN) were transmitted to RTI International, the data coordinating center (DCC) for the network, which stored, managed and analyzed the data for this study. On behalf of the NRN, Drs. Abhik Das (DCC Principal Investigator), Marie Gantz, and Barbara Do (DCC Statisticians) had full access to all the data in the study and take responsibility for the integrity of the data and accuracy of the data analysis. We are indebted to our medical and nursing colleagues and the infants and their parents who agreed to take part in this study. The following investigators, in addition to those listed as authors, participated in this study: NRN Steering Committee Chairs: Alan H. Jobe, MD PhD, University of Cincinnati (2003-2006); Michael S. Caplan, MD, University of Chicago, Pritzker School of Medicine (2006-2011); Richard A. Polin, MD, Division of Neonatology, College of Physicians and Surgeons, Columbia University, (2011-present). Alpert Medical School of Brown University and Women & Infants Hospital of Rhode Island (U10 HD27904) – Abbot R. Laptook, MD; Angelita M. Hens-man, MS RNC-NIC; Victoria E. Watson, MS CAS; Elisabeth C. McGowan, MD; Elisa Vieira, RN BSN; Emilee Little, RN BSN; Katharine Johnson, MD; Barbara Alksninis, PNP; Mary Lenore Kes-zler, MD; Andrea M. Knoll; Theresa M. Leach, MEd CAES; Victoria E. Watson, MS CAS. Case Western Reserve University, Rainbow Babies & Children’s Hospital (U10 HD21364, M01 RR80) – Michele C. Walsh, MD MS; Maureen Hack, MD (deceased); H. Gerry Taylor, PhD; Deanne E. Wilson-Costello, MD; Allison Payne, MD MSCR; Nancy S. Newman, RN; Bonnie S. Siner, RN; Arlene Zadell, RN; Julie DiFiore, BS; Monika Bhola, MD; Harriet G. Friedman, MA; Gulgun Yalcinkaya, MD. Cincinnati Children’s Hospital Medical Center (UG1 HD27853) – Kurt Schibler MD; Kimberly Yolton, PhD; Department of Diagnostic Imaging and Radiology, Children’s National Medical Center, Washington DC – Dorothy Bulas, MD. Duke University School of Medicine, University Hospital, and Duke Regional Hospital (U10 HD40492, M01 RR30) – Ronald N. Goldberg, MD; C. Michael Cotten, MD MHS; Ricki F. Goldstein, MD; Kathryn E. Gustafson, PhD; Ricki F. Goldstein, MD; Patricia Ashley, MD; Kathy J. Auten, MSHS; Kimberley A. Fisher, PhD FNP-BC IBCLC; Katherine A. Foy, RN; Sharon F. Freedman, MD; Melody B. Lohmeyer, RN MSN; William F. Malcolm, MD; David K. Wallace, MD MPH. Emory University, Children’s Healthcare of Atlanta, Grady Memorial Hospital, and Emory Crawford Long Hospital (U10 HD27851, RR25008, M01 RR39) – David P. Carlton, MD; Barbara J. Stoll, MD; Ira Adams-Chapman, MD; Susie Buchter, MD; Anthony J. Piazza, MD; Sheena Carter, PhD; Sobha Fritz, PhD; Ellen C. Hale, RN BS CCRC; Amy K. Hutchinson, MD; Maureen Mulligan LaRossa, RN; Yvonne Loggins, RN, Diane Bottcher, RN. Eunice Kennedy Shriver National Institute of Child Health and Human Development – Stephanie Wilson Archer, MA. Indiana University, University Hospital, Methodist Hospital, Riley Hospital for Children, and Wishard Health Services (U10 HD27856, M01 RR750) – Brenda B. Poindexter, MD MS; Gregory M. Sokol, MD; Heidi M. Harmon, MD MS; Lu-Ann Papile, MD; Abbey C. Hines, PsyD; Leslie D. Wilson, BSN CCRC; Dianne E. Herron, RN; Lucy Smiley, CCRC. McGovern Medical School at The University of Texas Health Science Center at Houston and Children's Memorial Hermann Hospital (U10 HD21373) – Kathleen A. Kennedy, MD MPH; Jon E. Tyson, MD MPH; Andrea Freeman Duncan, MD; Allison G. Dempsey, PhD; Janice John, CPNP; Patrick M. Jones, MD MA; M. Layne Lillie, RN BSN; Saba Siddiki, MD; Daniel K. Sperry, RN. National Heart, Lung, and Blood Institute – Mary Anne Berberich, PhD; Carol J. Blaisdell, MD; Dorothy B. Gail, PhD; James P. Kiley, PhD. RTI International (U10 HD36790) – Dennis Wallace, PhD; Marie G. Gantz, PhD; Carla M. Bann, PhD; Jamie E. Newman, PhD MPH; Jeanette O’Donnell Auman, BS; Jane A. Hammond, PhD; W. Kenneth Poole, PhD (deceased). Stanford University and Lucile Packard Children's Hospital (U10 HD27880, UL1 RR25744, M01 RR70) – Krisa P. Van Meurs, MD; David K. Stevenson, MD; Patrick D. Barnes, MD; Maria Elena DeAnda, PhD; M. Bethany Ball, BS CCRC; Gabrielle T. Goodlin, BAS. Tufts Medical Center, Floating Hospital for Children (U10 HD53119, M01 RR54) – Ivan D. Frantz III, MD; John M. Fiascone, MD; Elisabeth C. McGowan, MD; Anne Furey, MPH; Brenda L. MacKinnon, RNC; Ellen Nylen, RN BSN; Ana Brussa, MS OTR/L; Cecelia Sibley, PT MHA. University of Alabama at Birmingham Health System and Children’s Hospital of Alabama (U10 HD34216, M01 RR32) – Waldemar A. Carlo, MD; Namasivayam Ambalavanan, MD; Myriam Peralta-Carcelen, MD; Monica V. Collins, RN BSN MaEd; Shirley S. Cosby, RN BSN; Vivien A. Phillips, RN BSN; Kristy Domanovich, PhD; Sally Whitley, MA OTR-L FAOTA; Leigh Ann Smith CRNP, Carin R. Kiser, MD. University of California – San Diego Medical Center and Sharp Mary Birch Hospital for Women (U10 HD40461) – Neil N. Finer, MD; Yvonne E. Vaucher, MD MPH; Donna Garey, MD MPH; Maynard R. Rasmussen; MD; Paul R. Wozniak, MD; Martha G. Fuller, PhD RN; Natacha Akshoomoff, PhD; Wade Rich, BSHS RRT; Kathy Arnell, RNC; Renee Bridge, RN. University of Iowa (U10 HD53109, UL1 TR442, M01 RR59) – Edward F. Bell, MD; Tarah T. Colaizy, MD; John A. Widness, MD; Jonathan M. Klein, MD; Karen J. Publisher Copyright: © 2020, The Author(s), under exclusive licence to Springer Nature America, Inc.
PY - 2020/6/1
Y1 - 2020/6/1
N2 - Objective: To explore the relationship between neonatal oxygen saturation and BP at age 6–7 years in a cohort of infants born extremely preterm. Study design: Infants <28 weeks gestation were assigned to a higher or lower oxygen saturation target. Oximeter data were monitored throughout the neonatal period. A subset of survivors was seen at age 6. BP was measured and compared by group assignment, achieved saturations, and time spent in hypoxemia (saturations <80%). Results: There was no difference in systolic or diastolic BP between assigned groups. Median achieved weekly oxygen saturation was not associated with BP. Longer duration of hypoxemia during the first week of age was associated with higher systolic BP. Conclusions: Neither target nor actual median oxygen saturations in this study was associated with BP at school age. Increased duration of hypoxemia in the first postnatal week was associated with higher systolic BP at 6–7 years of age.
AB - Objective: To explore the relationship between neonatal oxygen saturation and BP at age 6–7 years in a cohort of infants born extremely preterm. Study design: Infants <28 weeks gestation were assigned to a higher or lower oxygen saturation target. Oximeter data were monitored throughout the neonatal period. A subset of survivors was seen at age 6. BP was measured and compared by group assignment, achieved saturations, and time spent in hypoxemia (saturations <80%). Results: There was no difference in systolic or diastolic BP between assigned groups. Median achieved weekly oxygen saturation was not associated with BP. Longer duration of hypoxemia during the first week of age was associated with higher systolic BP. Conclusions: Neither target nor actual median oxygen saturations in this study was associated with BP at school age. Increased duration of hypoxemia in the first postnatal week was associated with higher systolic BP at 6–7 years of age.
UR - http://www.scopus.com/inward/record.url?scp=85081288863&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85081288863&partnerID=8YFLogxK
U2 - 10.1038/s41372-020-0619-z
DO - 10.1038/s41372-020-0619-z
M3 - Article
C2 - 32111975
AN - SCOPUS:85081288863
SN - 0743-8346
VL - 40
SP - 902
EP - 908
JO - Journal of Perinatology
JF - Journal of Perinatology
IS - 6
ER -