Near-infrared-induced heating of confined water in polymeric particles for efficient payload release

Mathieu L. Viger, Wangzhong Sheng, Kim Doré, Ali H. Alhasan, Carl Johan Carling, Jacques Lux, Caroline De Gracia Lux, Madeleine Grossman, Roberto Malinow, Adah Almutairi

Research output: Contribution to journalArticlepeer-review

68 Scopus citations


Near-infrared (NIR) light-triggered release from polymeric capsules could make a major impact on biological research by enabling remote and spatiotemporal control over the release of encapsulated cargo. The few existing mechanisms for NIR-triggered release have not been widely applied because they require custom synthesis of designer polymers, high-powered lasers to drive inefficient two-photon processes, and/or coencapsulation of bulky inorganic particles. In search of a simpler mechanism, we found that exposure to laser light resonant with the vibrational absorption of water (980 nm) in the NIR region can induce release of payloads encapsulated in particles made from inherently non-photo-responsive polymers. We hypothesize that confined water pockets present in hydrated polymer particles absorb electromagnetic energy and transfer it to the polymer matrix, inducing a thermal phase change. In this study, we show that this simple and highly universal strategy enables instantaneous and controlled release of payloads in aqueous environments as well as in living cells using both pulsed and continuous wavelength lasers without significant heating of the surrounding aqueous solution.

Original languageEnglish (US)
Pages (from-to)4815-4826
Number of pages12
JournalACS Nano
Issue number5
StatePublished - May 27 2014


  • confined water
  • near-infrared radiation
  • photothermal effect
  • polymeric carriers
  • triggered release

ASJC Scopus subject areas

  • Materials Science(all)
  • Engineering(all)
  • Physics and Astronomy(all)


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