Natural History of Primary Biliary Cirrhosis

Research output: Contribution to journalReview articlepeer-review

34 Scopus citations


Primary biliary cirrhosis is an insidious disease that progresses through the clinical phases: preclinical, asymptomatic, symptomatic, and liver insufficiency. The outlook of patients diagnosed with PBC has improved significantly over the past 2 decades because more patients are being diagnosed earlier in the disease process and being treated with UDCA. A need remains to better define and predict the course of symptomatic and asymptomatic patients on and off UDCA in order to better evaluate outcomes of clinical trials.

Original languageEnglish (US)
Pages (from-to)277-288
Number of pages12
JournalClinics in Liver Disease
Issue number2
StatePublished - May 1 2008

ASJC Scopus subject areas

  • Hepatology


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