Natriuretic peptides: Physiology for the clinician

Siu Hin Wan, Horng H. Chen

Research output: Chapter in Book/Report/Conference proceedingChapter


Natriuretic peptides (NPs) are a family of hormones that have significant cardiorenal properties. As an important component of blood pressure homeostasis in humans, NPs are potent vasodilatory hormones that mediate diuresis, natriuresis and cardiac remodeling (Levin et al., N Engl J Med 339(5):321-328, 1998). Neurohormonal signaling plays an essential role in cardiovascular disease. Whereas antagonism of the renin-angiotensin-aldosterone pathway, a mediator of provascocontriction, leads to improved outcomes in heart failure, the potentiation of the NPs leads to vasodilation and improved cardiac remodeling. Therefore, NPs have been investigated both as a biomarker for cardiovascular disease as well as a potential treatment agent.

Original languageEnglish (US)
Title of host publicationCardiac Biomarkers
Subtitle of host publicationCase Studies and Clinical Correlations
PublisherSpringer International Publishing
Number of pages12
ISBN (Electronic)9783319429823
ISBN (Print)9783319429809
StatePublished - Jan 1 2016
Externally publishedYes


  • Atrial natriuretic peptide (ANP)
  • B-type natriuretic peptide (BNP)
  • C-type natriuretic peptide
  • Cardiovascular properties of natriuretic peptides
  • Natriuretic peptides
  • Therapeutic modalities for heart failure

ASJC Scopus subject areas

  • General Medicine


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