TY - JOUR
T1 - Natriuretic peptides and cardiometabolic health
AU - Gupta, Deepak K.
AU - Wang, Thomas J.
N1 - Publisher Copyright:
© 2015, Official Journal of the Japanese Circulation Society. All right reserved.
PY - 2015/7/24
Y1 - 2015/7/24
N2 - Natriuretic peptides are cardiac-derived hormones with a range of protective functions, including natriuresis, diuresis, vasodilation, lusitropy, lipolysis, weight loss, and improved insulin sensitivity. Their actions are mediated through membrane-bound guanylyl cyclases that lead to production of the intracellular second-messenger cyclic guanosine monophosphate. A growing body of evidence demonstrates that genetic and acquired deficiencies of the natriuretic peptide system can promote hypertension, cardiac hypertrophy, obesity, diabetes mellitus, the metabolic syndrome, and heart failure. Clinically, natriuretic peptides are robust diagnostic and prognostic markers, and augmenting natriuretic peptides is a target for therapeutic strategies in cardiometabolic disease. This review will summarize current understanding and highlight novel aspects of natriuretic peptide biology.
AB - Natriuretic peptides are cardiac-derived hormones with a range of protective functions, including natriuresis, diuresis, vasodilation, lusitropy, lipolysis, weight loss, and improved insulin sensitivity. Their actions are mediated through membrane-bound guanylyl cyclases that lead to production of the intracellular second-messenger cyclic guanosine monophosphate. A growing body of evidence demonstrates that genetic and acquired deficiencies of the natriuretic peptide system can promote hypertension, cardiac hypertrophy, obesity, diabetes mellitus, the metabolic syndrome, and heart failure. Clinically, natriuretic peptides are robust diagnostic and prognostic markers, and augmenting natriuretic peptides is a target for therapeutic strategies in cardiometabolic disease. This review will summarize current understanding and highlight novel aspects of natriuretic peptide biology.
KW - Cardiometabolic disease
KW - Genetics
KW - Guanylyl cyclase
KW - Natriuretic peptides
KW - Neprilysin
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U2 - 10.1253/circj.CJ-15-0589
DO - 10.1253/circj.CJ-15-0589
M3 - Article
C2 - 26103984
AN - SCOPUS:84937848194
SN - 1346-9843
VL - 79
SP - 1648
EP - 1655
JO - Circulation Journal
JF - Circulation Journal
IS - 8
ER -