Abstract
Intracellular pathogens like Salmonella evade host phagocytic killing by various mechanisms. Classical antimicrobial therapy requires multiple dosages and frequent administration of drugs for a long duration. Intracellular delivery of antimicrobials using nanoparticle may effectively devise therapies for bacterial infections. This review will address the mechanisms used by Salmonella to avoid host pathogenic killing, reasons for therapeutic failure and advances in nanoparticle drug delivery technology for efficient intracellular bacterial clearance.
Original language | English (US) |
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Pages (from-to) | 1-9 |
Number of pages | 9 |
Journal | FEMS Microbiology Letters |
Volume | 332 |
Issue number | 1 |
DOIs | |
State | Published - Jul 2012 |
Externally published | Yes |
Keywords
- Drug delivery
- Intracelluar infection
- Nanoparticle
ASJC Scopus subject areas
- Microbiology
- Molecular Biology
- Genetics