Nano-antacids enhance pH neutralization beyond their bulk counterparts: Synthesis and characterization

Ramesh Raliya, Avik Som, Nishit Shetty, Nathan Reed, Samuel Achilefu, Pratim Biswas

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Antacids are crucial in the treatment of gastro-esophageal reflux disease and peptic ulcers. Antacids based on the calcite phase of bulk calcium carbonate have been the standard for over fifty years. More recent research has shown that nanomaterial forms of such bulk materials often have improved properties. However, the metastable vaterite form of calcium carbonate is particularly difficult to synthesize as a nanomaterial, and thus has not been extensively studied. Here, we describe the synthesis of these particles and investigate them for antacid applications. Experimental and computational approaches show that nanoscale vaterite particles maintain neutral gastric pH values three times longer than commercial antacids.

Original languageEnglish (US)
Pages (from-to)54331-54335
Number of pages5
JournalRSC Advances
Issue number59
StatePublished - 2016
Externally publishedYes

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)


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