TY - JOUR
T1 - NaBC1 is a ubiquitous electrogenic Na+-coupled borate transporter essential for cellular boron homeostasis and cell growth and proliferation
AU - Park, Meeyoung
AU - Li, Qin
AU - Shcheynikov, Nikolay
AU - Zeng, Weizong
AU - Muallem, Shmuel
N1 - Funding Information:
This work was supported by NIH grants DE12309 and DK38938.
PY - 2004/11/5
Y1 - 2004/11/5
N2 - Boron is a vital micronutrient in plants and may be essential for animal growth and development. Whereas the role of boron in the life cycle of plants is well documented, nothing is known about boron homeostasis and function in animal cells. NaBC1, the mammalian homolog of AtBor1, is a borate transporter. In the absence of borate, NaBC1 conducts Na+ and OH- (H+), while in the presence of borate, NaBC1 functions as an electrogenic, voltage-regulated, Na+-coupled B(OH)4 - transporter. At low concentrations, borate activated the MAPK pathway to stimulate cell growth and proliferation, and at high concentrations, it was toxic. Accordingly, overexpression of NaBC1 shifted both effects of borate to the left, whereas knockdown of NaBC1 halted cell growth and proliferation. These findings may reveal a previously unrecognized role for NaBC1 in borate homeostasis and open the way to better understanding of the many presumed physiological roles of borate in animals.
AB - Boron is a vital micronutrient in plants and may be essential for animal growth and development. Whereas the role of boron in the life cycle of plants is well documented, nothing is known about boron homeostasis and function in animal cells. NaBC1, the mammalian homolog of AtBor1, is a borate transporter. In the absence of borate, NaBC1 conducts Na+ and OH- (H+), while in the presence of borate, NaBC1 functions as an electrogenic, voltage-regulated, Na+-coupled B(OH)4 - transporter. At low concentrations, borate activated the MAPK pathway to stimulate cell growth and proliferation, and at high concentrations, it was toxic. Accordingly, overexpression of NaBC1 shifted both effects of borate to the left, whereas knockdown of NaBC1 halted cell growth and proliferation. These findings may reveal a previously unrecognized role for NaBC1 in borate homeostasis and open the way to better understanding of the many presumed physiological roles of borate in animals.
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U2 - 10.1016/j.molcel.2004.09.030
DO - 10.1016/j.molcel.2004.09.030
M3 - Article
C2 - 15525507
AN - SCOPUS:8644251840
SN - 1097-2765
VL - 16
SP - 331
EP - 341
JO - Molecular cell
JF - Molecular cell
IS - 3
ER -