TY - CHAP
T1 - Myosin light chain kinases
AU - Kemp, Bruce E.
AU - Stull, James T.
N1 - Funding Information:
Acknowledgments: The authors disclose any conflict of interest in the present review. The Laboratory of Morphometry, Metabolism, and Cardiovascular Diseases (www.lmmc.uerj.br) is currently sponsored by the following grants: a) Fundação Carlos Chagas Filho de Amparo à Pesquisa do Rio de Janeiro (FAPERJ), grant numbers 202.126/2015 to TCLB, 202.888/2015 to VSM, 201.335/2014 to MBA, and 201.186/2014 to CAML. b) Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq), grant numbers 306.077/2013-2 to MBA, and 302.154/2011-6 to CAML.
Publisher Copyright:
© 1990 by CRC Press, Inc.
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Ca2+ is a second messenger that activates many Ca2+-dependent cellular processes. Ca2+ has been recognized as an important component in muscle contraction and cell motility because it regulates a distinct class of protein kinases, myosin light chain kinases.1-3 Activation of myosin light chain kinase by Ca2+/calmodulin results in phosphorylation of a regulatory light chain subunit of myosin. Myosin light chain phosphorylation leads to potentiation of contraction in striated muscles, but initiates contraction in smooth muscles. Before reviewing the catalytic properties of myosin light chain kinases, a general discussion of contractile proteins and the role of myosin phosphorylation will be presented so that the reader will have some appreciation of the biological importance of this class of kinases. The main topic, however, will deal with their respective biochemical properties as elucidated with peptides.
AB - Ca2+ is a second messenger that activates many Ca2+-dependent cellular processes. Ca2+ has been recognized as an important component in muscle contraction and cell motility because it regulates a distinct class of protein kinases, myosin light chain kinases.1-3 Activation of myosin light chain kinase by Ca2+/calmodulin results in phosphorylation of a regulatory light chain subunit of myosin. Myosin light chain phosphorylation leads to potentiation of contraction in striated muscles, but initiates contraction in smooth muscles. Before reviewing the catalytic properties of myosin light chain kinases, a general discussion of contractile proteins and the role of myosin phosphorylation will be presented so that the reader will have some appreciation of the biological importance of this class of kinases. The main topic, however, will deal with their respective biochemical properties as elucidated with peptides.
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U2 - 10.1201/9781351075442
DO - 10.1201/9781351075442
M3 - Chapter
AN - SCOPUS:85053094485
SN - 0849365309
SN - 9781315896342
SP - 116
EP - 133
BT - Peptides and Protein Phosphorylation
PB - CRC Press
ER -