Myocardial infarction in sickle cell disease

Ishak A. Mansi, Fred Rosner

Research output: Contribution to journalArticlepeer-review

31 Scopus citations


Vasculo-occlusive crisis with organ infarctions occur in sickle cell disease (SCD). However, heart infarction is not commonly reported. We reviewed 19 cases of documented myocardial infarction (MI) in SCD patients. The true incidence may be higher because the diagnosis was often made at autopsy and was overshadowed during life by other musculoskeletal symptoms. Electrocardiography is frequently unhelpful. Skeletal muscle enzymes confound serum cardiac enzyme interpretation. The mechanism of MI in SCD is not exactly known, as coronary angiography is usually normal. MI frequently occurs in association with hypoxia, cor pulmonale, anemia, sepsis, acidosis, and renal failure. The aim of this article is to increase awareness for this complication and to prompt prospective studies to look at treatment strategies for myocardial infarction in SCD.

Original languageEnglish (US)
Pages (from-to)448-452
Number of pages5
JournalJournal of the National Medical Association
Issue number6
StatePublished - Jun 2002


  • Magnesium
  • Myocardial infarction
  • Nitrates
  • Sickle cell disease

ASJC Scopus subject areas

  • Medicine(all)


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