TY - JOUR
T1 - Myeloid/lymphoid neoplasm with ZMYM2::FGFR1 rearrangement: A complex trilineage phenotypic and clonal evolution with associated genomic alterations
AU - Chen, Dong
AU - Liu, Guang
AU - Lewis, Michael R.
AU - Li, Xia
AU - Ulrickson, Matthew
AU - Nath, Rajneesh
AU - Chen, Weina
N1 - Publisher Copyright:
© 2023
PY - 2023/1
Y1 - 2023/1
N2 - We report a case of myeloid/lymphoid neoplasm with ZMYM2::FGFR1 rearrangement (MLNZMYM2::FGFR1) exhibiting a complex disease evolution. This neoplasm initially presented as T-lymphoblastic lymphoma (T-LBL) in lymph node and myeloproliferative neoplasm (MPN) with eosinophilia in bone marrow, then transitioned to systemic mastocytosis (SM) likely accompanied by additional JAK3 and other mutations and finally transformed to acute myeloid leukemia (AML) accompanied by additional/secondary genetic abnormality (gain of chromosome 21, der(13)t(8;13), and RUNX1 mutation). To our knowledge, this is the first case of MLNZMYM2::FGFR1 with a complex trilineage/phenotypic [T-cell (T-LBL), mast cell (SM), and myeloid (MPN and AML)] lineage evolution.
AB - We report a case of myeloid/lymphoid neoplasm with ZMYM2::FGFR1 rearrangement (MLNZMYM2::FGFR1) exhibiting a complex disease evolution. This neoplasm initially presented as T-lymphoblastic lymphoma (T-LBL) in lymph node and myeloproliferative neoplasm (MPN) with eosinophilia in bone marrow, then transitioned to systemic mastocytosis (SM) likely accompanied by additional JAK3 and other mutations and finally transformed to acute myeloid leukemia (AML) accompanied by additional/secondary genetic abnormality (gain of chromosome 21, der(13)t(8;13), and RUNX1 mutation). To our knowledge, this is the first case of MLNZMYM2::FGFR1 with a complex trilineage/phenotypic [T-cell (T-LBL), mast cell (SM), and myeloid (MPN and AML)] lineage evolution.
KW - Acute myeloid leukemia
KW - Myeloid/lymphoid neoplasm with FGFR1 rearrangement (MLN)
KW - Systemic mastocytosis
KW - T-lymphoblastic lymphoma
KW - ZMYM2::FGFR1
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U2 - 10.1016/j.lrr.2023.100370
DO - 10.1016/j.lrr.2023.100370
M3 - Article
C2 - 37275466
AN - SCOPUS:85160529438
SN - 2213-0489
VL - 19
JO - Leukemia Research Reports
JF - Leukemia Research Reports
M1 - 100370
ER -