@article{409d2f1b05824e8e9fe79b3991963b9e,
title = "Muscle as a {"}mediator{"} of systemic metabolism",
abstract = "Skeletal and cardiac muscles play key roles in the regulation of systemic energy homeostasis and display remarkable plasticity in their metabolic responses to caloric availability and physical activity. In this Perspective we discuss recent studies highlighting transcriptional mechanisms that govern systemic metabolism by striated muscles. We focus on the participation of the Mediator complex in this process, and suggest that tissue-specific regulation of Mediator subunits impacts metabolic homeostasis.",
author = "Baskin, {Kedryn K.} and Winders, {Benjamin R.} and Olson, {Eric N.}",
note = "Funding Information: We apologize to our colleagues whose work could not be cited due to space limitations and our narrowly focused Perspective. We thank Dr. Angie L. Bookout for thought-provoking discussions and careful reading of the manuscript, and Jose Cabrera for the graphics. This work was supported by grants from the NIH (HL-077439, HL-111665, HL-093039, DK-099653, and U01-HL-100401), Foundation Leducq Networks of Excellence, Cancer Prevention & Research Institute of Texas, and the Robert A. Welch Foundation (grant 1-0025 to E.N.O.). K.K.B. was supported by a fellowship from the American Heart Association (14POST18320034), and B.R.W. was supported by NIH T32 grant. Publisher Copyright: {\textcopyright} 2015 Elsevier Inc.",
year = "2015",
month = feb,
day = "3",
doi = "10.1016/j.cmet.2014.12.021",
language = "English (US)",
volume = "21",
pages = "237--248",
journal = "Cell Metabolism",
issn = "1550-4131",
publisher = "Cell Press",
number = "2",
}