Muscle as a "mediator" of systemic metabolism

Kedryn K. Baskin, Benjamin R. Winders, Eric N. Olson

Research output: Contribution to journalReview articlepeer-review

166 Scopus citations


Skeletal and cardiac muscles play key roles in the regulation of systemic energy homeostasis and display remarkable plasticity in their metabolic responses to caloric availability and physical activity. In this Perspective we discuss recent studies highlighting transcriptional mechanisms that govern systemic metabolism by striated muscles. We focus on the participation of the Mediator complex in this process, and suggest that tissue-specific regulation of Mediator subunits impacts metabolic homeostasis.

Original languageEnglish (US)
Pages (from-to)237-248
Number of pages12
JournalCell Metabolism
Issue number2
StatePublished - Feb 3 2015

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cell Biology


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