Muscle as a "mediator" of systemic metabolism

Kedryn K. Baskin; Benjamin R. Winders; Eric N. Olson

doi:10.1016/j.cmet.2014.12.021

Muscle as a "mediator" of systemic metabolism

Kedryn K. Baskin, Benjamin R. Winders, Eric N. Olson

Research output: Contribution to journal › Review article › peer-review

186 Scopus citations

Abstract

Skeletal and cardiac muscles play key roles in the regulation of systemic energy homeostasis and display remarkable plasticity in their metabolic responses to caloric availability and physical activity. In this Perspective we discuss recent studies highlighting transcriptional mechanisms that govern systemic metabolism by striated muscles. We focus on the participation of the Mediator complex in this process, and suggest that tissue-specific regulation of Mediator subunits impacts metabolic homeostasis.

Original language	English (US)
Pages (from-to)	237-248
Number of pages	12
Journal	Cell Metabolism
Volume	21
Issue number	2
DOIs	https://doi.org/10.1016/j.cmet.2014.12.021
State	Published - Feb 3 2015

ASJC Scopus subject areas

Physiology
Molecular Biology
Cell Biology

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10.1016/j.cmet.2014.12.021

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Muscle as a "mediator" of systemic metabolism

Abstract

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