Abstract
Previous work in this laboratory demonstrated that a population of cultured midterm murine trophoblast cells are not susceptible to lysis by allospecific cytotoxic T lymphocytes (CTL) generated by standard in vitro protocols. We now report that this trophoblast population is killed, in an MHC-dependent manner, by allospecific CTL generated in GIBCO Opti-MEM, a modified tissue culture medium designed to maintain cell growth and proliferation in the presence of low concentrations of fetal bovine serum (FBS).
| Original language | English (US) |
|---|---|
| Pages (from-to) | 71-77 |
| Number of pages | 7 |
| Journal | Journal of reproductive immunology |
| Volume | 15 |
| Issue number | 1 |
| DOIs | |
| State | Published - Mar 1989 |
Keywords
- cytotoxic T lymphocytes
- in vitro susceptibility
- murine trophoblast
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Reproductive Medicine
- Obstetrics and Gynecology