TY - JOUR
T1 - Muramyl dipeptide-induced changes in murine splenocyte responses to concanavalin A
AU - Dozmorov, Igor M.
AU - Bagaeva, Lyudmila V.
AU - Kuzin, Igor I.
AU - Sapozhnikov, Alexander M.
AU - Svirshchevskaya, Elena V.
AU - Andronova, Tatyana M.
AU - Petrov, Rem V.
PY - 1992/2
Y1 - 1992/2
N2 - The effect of muramyl dipeptide (MDP) on Con A-stimulated activation of murine spleen cells was studied. MDP was found to enhance or suppress the proliferative response of splenocytes when different concentrations of Con A were used. MDP was shown to change the IL-2 content in culture supernatants of stimulated cells and to influence IL-2-dependent proliferation of Con A-blasts. A high degree of correlation was found between the proliferation of Con A-blasts and the expression of IL-2 receptors on Con A-blasts. This correlation, however, disappeared in the presence of MDP. The effects of MDP were shown to depend on the level of initial cell activity or rather on conditions leading to a given initial activity of cells.
AB - The effect of muramyl dipeptide (MDP) on Con A-stimulated activation of murine spleen cells was studied. MDP was found to enhance or suppress the proliferative response of splenocytes when different concentrations of Con A were used. MDP was shown to change the IL-2 content in culture supernatants of stimulated cells and to influence IL-2-dependent proliferation of Con A-blasts. A high degree of correlation was found between the proliferation of Con A-blasts and the expression of IL-2 receptors on Con A-blasts. This correlation, however, disappeared in the presence of MDP. The effects of MDP were shown to depend on the level of initial cell activity or rather on conditions leading to a given initial activity of cells.
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U2 - 10.1016/0192-0561(92)90026-H
DO - 10.1016/0192-0561(92)90026-H
M3 - Article
C2 - 1624217
AN - SCOPUS:0026551814
SN - 0192-0561
VL - 14
SP - 159
EP - 165
JO - International Journal of Immunopharmacology
JF - International Journal of Immunopharmacology
IS - 2
ER -