TY - JOUR
T1 - Multimodality Hyperpolarized C-13 MRS/PET/Multiparametric MR Imaging for Detection and Image-Guided Biopsy of Prostate Cancer
T2 - First Experience in a Canine Prostate Cancer Model
AU - Bachawal, Sunitha V.
AU - Park, Jae Mo
AU - Valluru, Keerthi S.
AU - Loft, Mathias Dyrberg
AU - Felt, Stephen A.
AU - Vilches-Moure, José G.
AU - Saenz, Yamil F.
AU - Daniel, Bruce
AU - Iagaru, Andrei
AU - Sonn, Geoffrey
AU - Cheng, Zhen
AU - Spielman, Daniel M.
AU - Willmann, Jürgen K.
N1 - Funding Information:
The canine PCa cells (Ace-1) were obtained from Dr. Thomas Rosol, Department of Veterinary Biosciences, Ohio State University. We would like to thank Philips for providing the EPIQ7 ultrasound system, C10-4ec transducer, and PercuNav image fusion software. We thank Praveen Gulaka, Valentina Taviani, Dawn Holley, and Harsh Gandhi for their assistance with PET/MR acquisition and reconstruction; Jim Strommer for help with Fig. 1 ; Don Samaan from Health Physics; veterinary service center staff; and members of Willmann, Spielman, Cheng labs, and Frezghi Habte who helped with this study.
Publisher Copyright:
© 2019, World Molecular Imaging Society.
PY - 2019/10/1
Y1 - 2019/10/1
N2 - Purpose: To assess whether simultaneous hyperpolarized C-13 magnetic resonance spectroscopy (MRS)/positron emission tomography (PET)/multiparametric magnetic resonance (mpMR) imaging is feasible in an orthotopic canine prostate cancer (PCa) model using a clinical PET/MR system and whether the combined imaging datasets can be fused with transrectal ultrasound (TRUS) in real time for multimodal image fusion-guided targeted biopsy of PCa. Procedures: Institutional Animal Care and Use Committee approval was obtained for this study. Canine prostate adenocarcinoma (Ace-1) cells were orthotopically injected into the prostate of four dogs. Once tumor engraftment was confirmed by TRUS, simultaneous hyperpolarized C-13 MRS of [1-13C]pyruvate, PET (2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG), [68Ga]NODAGA-SCH1), and mpMR (T2W, DWI) imaging was performed using a clinical PET/MR system. Multimodality imaging data sets were then fused with TRUS and image-guided targeted biopsy was performed. Imaging results were then correlated with histological findings. Results: Successful tumor engraftment was histologically confirmed in three of the four dogs (dogs 2, 3, and 4) and simultaneous C-13 MRS/PET/mpMR was feasible in all three. In dog 2, C-13 MRS showed increased lactate signal in the tumor (lactate/totalC = 0.47) whereas mpMR did not show any signal changes. In dog 3, [18F]FDG-PET (SUVmean = 1.90) and C-13 MRS (lactate/totalC = 0.59) showed elevated metabolic activity in the tumor. In dog 4, [18F]FDG (SUVmean = 2.43), [68Ga]NODAGA-SCH1 (SUVmean = 0.75), and C-13 MRS (Lac/totalC = 0.53) showed elevated uptake in tumor compared to control tissue and multimodal image fusion-guided biopsy of the tumor was successfully performed. Conclusion: Simultaneous C-13 MRS/PET/mpMR imaging and multimodal image fusion-guided biopsy is feasible in a canine PCa model.
AB - Purpose: To assess whether simultaneous hyperpolarized C-13 magnetic resonance spectroscopy (MRS)/positron emission tomography (PET)/multiparametric magnetic resonance (mpMR) imaging is feasible in an orthotopic canine prostate cancer (PCa) model using a clinical PET/MR system and whether the combined imaging datasets can be fused with transrectal ultrasound (TRUS) in real time for multimodal image fusion-guided targeted biopsy of PCa. Procedures: Institutional Animal Care and Use Committee approval was obtained for this study. Canine prostate adenocarcinoma (Ace-1) cells were orthotopically injected into the prostate of four dogs. Once tumor engraftment was confirmed by TRUS, simultaneous hyperpolarized C-13 MRS of [1-13C]pyruvate, PET (2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG), [68Ga]NODAGA-SCH1), and mpMR (T2W, DWI) imaging was performed using a clinical PET/MR system. Multimodality imaging data sets were then fused with TRUS and image-guided targeted biopsy was performed. Imaging results were then correlated with histological findings. Results: Successful tumor engraftment was histologically confirmed in three of the four dogs (dogs 2, 3, and 4) and simultaneous C-13 MRS/PET/mpMR was feasible in all three. In dog 2, C-13 MRS showed increased lactate signal in the tumor (lactate/totalC = 0.47) whereas mpMR did not show any signal changes. In dog 3, [18F]FDG-PET (SUVmean = 1.90) and C-13 MRS (lactate/totalC = 0.59) showed elevated metabolic activity in the tumor. In dog 4, [18F]FDG (SUVmean = 2.43), [68Ga]NODAGA-SCH1 (SUVmean = 0.75), and C-13 MRS (Lac/totalC = 0.53) showed elevated uptake in tumor compared to control tissue and multimodal image fusion-guided biopsy of the tumor was successfully performed. Conclusion: Simultaneous C-13 MRS/PET/mpMR imaging and multimodal image fusion-guided biopsy is feasible in a canine PCa model.
KW - Hyperpolarized MR spectroscopy
KW - Image fusion
KW - Multimodality imaging
KW - Multiparametric MRI
KW - PET
KW - Prostate cancer
KW - Targeted biopsy
KW - Transrectal ultrasound
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U2 - 10.1007/s11307-018-1235-6
DO - 10.1007/s11307-018-1235-6
M3 - Article
C2 - 30793241
AN - SCOPUS:85062033795
SN - 1536-1632
VL - 21
SP - 861
EP - 870
JO - Molecular Imaging and Biology
JF - Molecular Imaging and Biology
IS - 5
ER -