Multi-Objective-Based Radiomic Feature Selection for Lesion Malignancy Classification

Zhiguo Zhou, Shulong Li, Genggeng Qin, Michael Folkert, Steve Jiang, Jing Wang

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


Objective: accurately classifying the malignancy of lesions detected in a screening scan is critical for reducing false positives. Radiomics holds great potential to differentiate malignant from benign tumors by extracting and analyzing a large number of quantitative image features. Since not all radiomic features contribute to an effective classifying model, selecting an optimal feature subset is critical. Methods: this work proposes a new multi-objective based feature selection (MO-FS) algorithm that considers sensitivity and specificity simultaneously as the objective functions during feature selection. For MO-FS, we developed a modified entropy-based termination criterion that stops the algorithm automatically rather than relying on a preset number of generations. We also designed a solution selection methodology for multi-objective learning that uses the evidential reasoning approach (SMOLER) to automatically select the optimal solution from the Pareto-optimal set. Furthermore, we developed an adaptive mutation operation to generate the mutation probability in MO-FS automatically. Results: we evaluated the MO-FS for classifying lung nodule malignancy in low-dose CT and breast lesion malignancy in digital breast tomosynthesis. Conclusion: the experimental results demonstrated that the feature set selected by MO-FS achieved better classification performance than features selected by other commonly used methods. Significance: the proposed method is general and more effective radiomic feature selection strategy.

Original languageEnglish (US)
Article number8654586
Pages (from-to)194-204
Number of pages11
JournalIEEE Journal of Biomedical and Health Informatics
Issue number1
StatePublished - Jan 2020


  • Radiomics
  • evidential reasoning
  • feature selection
  • lesion malignancy classification
  • multi-objective evolutionary algorithm

ASJC Scopus subject areas

  • Health Information Management
  • Health Informatics
  • Electrical and Electronic Engineering
  • Computer Science Applications


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