TY - GEN
T1 - Multi-color Raman nanotags for tumor cell biomarker detection
AU - Nyagilo, James
AU - Xiao, Ming
AU - Sun, Xiankai
AU - Davé, Digant P.
PY - 2009
Y1 - 2009
N2 - We report the synthesis and characterization of multi-color gold nanoparticle based tags (Raman Nanotags) for molecular imaging. The multi-color Raman Nanotags are PEGylated gold nanoparticles (AuNPs) encapsulating a Raman reporter dyes which can be functionalized with any ligand of interest for targeted molecular imaging. The Raman Nanotags synthesized with 65 nm gold nanoparticles exhibit the largest surface enhanced Raman scattering (SERS) signal. Results are presented quantify the measured SERS signal, dynamic range, reproducibility, and stability of Raman Nanotags. In vitro cell culture experiments for targeted biomarker detection using functionalized Raman Nanotags are also presented.
AB - We report the synthesis and characterization of multi-color gold nanoparticle based tags (Raman Nanotags) for molecular imaging. The multi-color Raman Nanotags are PEGylated gold nanoparticles (AuNPs) encapsulating a Raman reporter dyes which can be functionalized with any ligand of interest for targeted molecular imaging. The Raman Nanotags synthesized with 65 nm gold nanoparticles exhibit the largest surface enhanced Raman scattering (SERS) signal. Results are presented quantify the measured SERS signal, dynamic range, reproducibility, and stability of Raman Nanotags. In vitro cell culture experiments for targeted biomarker detection using functionalized Raman Nanotags are also presented.
UR - http://www.scopus.com/inward/record.url?scp=77950991433&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77950991433&partnerID=8YFLogxK
U2 - 10.1109/IEMBS.2009.5332780
DO - 10.1109/IEMBS.2009.5332780
M3 - Conference contribution
C2 - 19963924
AN - SCOPUS:77950991433
SN - 9781424432967
T3 - Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009
SP - 6314
EP - 6317
BT - Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society
PB - IEEE Computer Society
T2 - 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009
Y2 - 2 September 2009 through 6 September 2009
ER -