Mucinous cystic neoplasms of the pancreas associated with pregnancy: Two case reports

Fernando Revoredo, José De Vinatea, Gustavo Reaño, Luis Villanueva, Fritz Kometter, José Arenas, Patricio M. Polanco

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Rationale:Although rare, pancreatic neoplasms can occur during pregnancy, both in benign and malignant forms. Mucinous cystic neoplasms (MCNs) of the pancreas, a type of these neoplasms, are precursor lesions to invasive pancreatic cancer. The presence of the ovarian-type stroma is a defining feature.Patient concerns:The first case was a 38-year-old woman in her 18th week of pregnancy with abdominal pain that worsens a few weeks later. The second case was a 30-year-old woman in her 17th week of pregnancy with abdominal pain in the left hypochondrium.Diagnosis:The patients were under clinical examination and laboratory test including carbohydrate antigen 19-9 (CA 19-9) and carcinoembryonic antigen (CEA). Both patients had magnetic resonance imaging (MRI). The diagnosis of a MCNs of the pancreas was done preoperatively in the 2 cases.Interventions:Both patients underwent distal pancreatectomy during pregnancy. One of them was an emergency laparotomy because of a ruptured MCN.Outcomes:Both patients were completely recovered from distal pancreatectomy and continued to full term, delivering a healthy baby by Caesarean section. After 6 years of follow-up, the first patient underwent a total gastrectomy, because of a gastric cancer with carcinomatosis. Currently the 2 patients are still alive after 8 years and 5 years of follow-up, respectively.Lessons:Surgical resection of MCNs during pregnancy should be considered during the second trimester given common distal pancreas location, rapid growth, risk of spontaneous rupture, and malignant potential.

Original languageEnglish (US)
Pages (from-to)E21471
JournalMedicine (United States)
Issue number31
StatePublished - Jul 31 2020


  • mucinous cystic neoplasms
  • pancreas
  • pregnancy

ASJC Scopus subject areas

  • Medicine(all)


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