mTOR complexes in neurodevelopmental and neuropsychiatric disorders

Mauro Costa-Mattioli, Lisa M Monteggia

Research output: Contribution to journalReview articlepeer-review

259 Scopus citations


The mechanistic target of rapamycin (mTOR) acts as a highly conserved signaling "hub" that integrates neuronal activity and a variety of synaptic inputs. mTOR is found in two functionally distinct complexes, mTORC1 and mTORC2, that crucially control long-term synaptic efficacy and memory storage. Dysregulation of mTOR signaling is associated with neurodevelopmental and neuropsychiatric disorders. In this Review, we describe the most recent advances in studies of mTOR signaling in the brain and the possible mechanisms underlying the many different functions of the mTOR complexes in neurological diseases. In addition, we discuss the medical relevance of these findings.

Original languageEnglish (US)
Pages (from-to)1537-1543
Number of pages7
JournalNature neuroscience
Issue number11
StatePublished - Nov 2013

ASJC Scopus subject areas

  • Neuroscience(all)


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