mTOR complexes in neurodevelopmental and neuropsychiatric disorders

Mauro Costa-Mattioli; Lisa M Monteggia

doi:10.1038/nn.3546

mTOR complexes in neurodevelopmental and neuropsychiatric disorders

Mauro Costa-Mattioli, Lisa M Monteggia

Research output: Contribution to journal › Review article › peer-review

271 Scopus citations

Abstract

The mechanistic target of rapamycin (mTOR) acts as a highly conserved signaling "hub" that integrates neuronal activity and a variety of synaptic inputs. mTOR is found in two functionally distinct complexes, mTORC1 and mTORC2, that crucially control long-term synaptic efficacy and memory storage. Dysregulation of mTOR signaling is associated with neurodevelopmental and neuropsychiatric disorders. In this Review, we describe the most recent advances in studies of mTOR signaling in the brain and the possible mechanisms underlying the many different functions of the mTOR complexes in neurological diseases. In addition, we discuss the medical relevance of these findings.

Original language	English (US)
Pages (from-to)	1537-1543
Number of pages	7
Journal	Nature neuroscience
Volume	16
Issue number	11
DOIs	https://doi.org/10.1038/nn.3546
State	Published - Nov 2013

ASJC Scopus subject areas

General Neuroscience

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10.1038/nn.3546

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title = "mTOR complexes in neurodevelopmental and neuropsychiatric disorders",

abstract = "The mechanistic target of rapamycin (mTOR) acts as a highly conserved signaling {"}hub{"} that integrates neuronal activity and a variety of synaptic inputs. mTOR is found in two functionally distinct complexes, mTORC1 and mTORC2, that crucially control long-term synaptic efficacy and memory storage. Dysregulation of mTOR signaling is associated with neurodevelopmental and neuropsychiatric disorders. In this Review, we describe the most recent advances in studies of mTOR signaling in the brain and the possible mechanisms underlying the many different functions of the mTOR complexes in neurological diseases. In addition, we discuss the medical relevance of these findings.",

author = "Mauro Costa-Mattioli and Monteggia, {Lisa M}",

note = "Funding Information: We thank members of M.C.-M.{\textquoteright}s laboratory, K. Krnjevic and E.T. Kavalali for comments and discussion. The figures were designed by S. Buffington. This work was supported by US National Institutes of Health grants NS076708 (M.C.-M.), MH096816 (M.C.-M.) and MH070727 (L.M.M.), Department of Defense grant AR10254 (M.C.-M.), Searle award grant 09-SSP-211 (M.C.-M.), the Whitehall Foundation (M.C.-M.) and the International Mental Health Research Organization (L.M.M.).",

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mTOR complexes in neurodevelopmental and neuropsychiatric disorders

Abstract

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